Cardiac function in dogs with chronic Chagas cardiomyopathy undergoing autologous stem cell transplantation into the coronary arteries

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorCollege of Veterinary Medicine and Animal Science-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSousa, Marios G.-
Autor(es): dc.creatorPaulino-Junior, Daniel [UNESP]-
Autor(es): dc.creatorPascon, João P. E. [UNESP]-
Autor(es): dc.creatorPereira-Neto, Gláucia B. [UNESP]-
Autor(es): dc.creatorCarareto, Roberta-
Autor(es): dc.creatorChampion, Tatiana [UNESP]-
Autor(es): dc.creatorCamacho, Aparecido A. [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:02:33Z-
Data de disponibilização: dc.date.available2022-08-04T22:02:33Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2011-08-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/219714-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/219714-
Descrição: dc.descriptionThis study assessed the effects of a single intracoronary injection of autologous stem cells on the cardiac function of dogs with Chagas cardiomyopathy. Bone-marrow-derived stem cells were delivered into the right and left coronary arteries of 5 mature dogs with mildly compromised cardiac function due to chronic Chagas cardiomyopathy. Blood pressure and electrocardiographic and echocardiographic parameters were recorded at monthly intervals for 6 mo in the 3 dogs that survived. Although no changes were observed in the electrocardiogram and blood pressure, there was a significant increase in peak velocity of aortic flow 3 mo after stem cell transplantation. Pre-ejection period, isovolumic relaxation time, and the Tei index of myocardial performance were reduced significantly 4 mo after the procedure. All significant changes persisted to the end of the study. The results suggest that the transplantation of autologous bone-marrow-derived stem cells into the coronary arteries of dogs with Chagas cardiomyopathy may have a beneficial effect but the small number of dogs studied was a limitation.-
Descrição: dc.descriptionFederal University of Tocantins State (UFT) College of Veterinary Medicine and Animal Science, BR-153, Araguaina, Tocantins-
Descrição: dc.descriptionSão Paulo State University (UNESP) College of Agricultural and Veterinarian Sciences (FCAV), Via de Acesso Prof. Paulo Donato Castellane, Jaboticabal, São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) College of Agricultural and Veterinarian Sciences (FCAV), Via de Acesso Prof. Paulo Donato Castellane, Jaboticabal, São Paulo-
Formato: dc.format869-874-
Idioma: dc.languageen-
Relação: dc.relationCanadian Veterinary Journal-
???dc.source???: dc.sourceScopus-
Título: dc.titleCardiac function in dogs with chronic Chagas cardiomyopathy undergoing autologous stem cell transplantation into the coronary arteries-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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