In vitro and skin lesion cytokine profile in Brazilian patients with borderline tuberculoid and borderline lepromatous leprosy

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorInstituto Lauro de Souza Lima-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorVenturini, James [UNESP]-
Autor(es): dc.creatorSoares, Cléverson Teixeira-
Autor(es): dc.creatorBelone, Andréa de Faria Fernandes-
Autor(es): dc.creatorBarreto, Jaison Antonio-
Autor(es): dc.creatorUra, Somei-
Autor(es): dc.creatorLauris, José Roberto Pereira-
Autor(es): dc.creatorVilani-Moreno, Fátima Regina-
Data de aceite: dc.date.accessioned2022-08-04T22:02:23Z-
Data de disponibilização: dc.date.available2022-08-04T22:02:23Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2011-03-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/219653-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/219653-
Descrição: dc.descriptionObjective: We investigated the in vitro and skin lesions production of cytokines in non-treated borderline tuberculoid (BT) and borderline lepromatous (BL) patients. Patients and Methods: Seven untreated, non-reactional BT patients and 12 untreated, non-reactional BL patients were studied. Levels of the cytokines IFN-γ, IL-10, TGF-β1 and TNF-α were measured in supernantant of peripheral blood mononuclear cells (PBMC) cultures, stimulated with specific M. leprae antigen (sonicated and whole). The cytokines iNOS, IL-10 and TGF-β1 were detected by immunohistochemistry in skin biopsies. Results: BT patients produced higher levels of IFN-γ than BL patients; iNOS expression in skin lesions was also higher in BT patients. TGF-β1 was detected in more cells in BL patients; IL-10 expression was similar in both groups. There was a negative correlation between iNOS and TGF-β1 expression in skin biopsies, positive correlation between TGF-b1 in skin lesions and bacillary index, as well as positive correlation between iNOS detected in skin biopsies and PBMC IFN- γ production. Conclusions: The BT patients had a mainly a Th1-profile of cytokines in their skin lesions and BL patients had aTh2 profile. © Lepra.-
Descrição: dc.descriptionFaculdade de Medicina de Botucatu UNESP, Botucatu, SP-
Descrição: dc.descriptionEquipe Técnica de Patologia Instituto Lauro de Souza Lima, Bauru, SP-
Descrição: dc.descriptionServiço de Epidemiologia Instituto Lauro de Souza Lima, Bauru, SP-
Descrição: dc.descriptionDivisão de Pesquisa e Ensino Instituto Lauro de Souza Lima, Bauru, SP-
Descrição: dc.descriptionFaculdade de Odontologia de Bauru Universidade de São Paulo, Bauru, SP-
Descrição: dc.descriptionFaculdade de Medicina de Botucatu UNESP, Botucatu, SP-
Formato: dc.format25-35-
Idioma: dc.languageen-
Relação: dc.relationLeprosy Review-
???dc.source???: dc.sourceScopus-
Título: dc.titleIn vitro and skin lesion cytokine profile in Brazilian patients with borderline tuberculoid and borderline lepromatous leprosy-
Tipo de arquivo: dc.typelivro digital-
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