Expression profile of p63 in 127 patients with laryngeal squamous cell carcinoma

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorAristides Maltez Hospital-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of the State of São Paulo-
Autor(es): dc.contributorNational Cancer Institute-
Autor(es): dc.creatorBorba, M.-
Autor(es): dc.creatorCernea, C.-
Autor(es): dc.creatorDias, F.-
Autor(es): dc.creatorFaria, P.-
Autor(es): dc.creatorBacchi, C.-
Autor(es): dc.creatorBrandão, L.-
Autor(es): dc.creatorCosta, A.-
Data de aceite: dc.date.accessioned2022-08-04T22:02:10Z-
Data de disponibilização: dc.date.available2022-08-04T22:02:10Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2010-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1159/000319904-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/219584-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/219584-
Descrição: dc.descriptionObjectives: To evaluate p63 expression in laryngeal squamous cell carcinoma and its prognostic significance. Methods: p63 expression was examined by immunohistochemistry and scored in 127 patients with laryngeal squamous cell carcinomas. Results: Sixty-two cases had scored 3, sixty had scored 2, four had scored 1 and one case did not show any expression (48.8, 47.2, 3.1 and 0.8%, respectively). Overall survival was 73.9% at 24 months and 59.5% at 60 months. The disease-free survival was 77.2 and 75.1%, and the disease-specific survival was 79 and 67% at 24 and 60 months, respectively. Uni- and multivariate analysis identified that decreased immunoexpression of protein p63 was a statistically significant factor for the risk of recurrence and death by cancer. Conclusions: p63 expression was highly prevalent in laryngeal squamous cell carcinomas, and its underexpression was correlated with a worse prognosis. Copyright © 2010 S. Karger AG, Basel.-
Descrição: dc.descriptionAristides Maltez Hospital, R. Colmar Americano da Costa 519/202, Salvador da Bahia 41830-600-
Descrição: dc.descriptionUniversity of São Paulo, São Paulo-
Descrição: dc.descriptionUniversity of the State of São Paulo, São Paulo-
Descrição: dc.descriptionNational Cancer Institute, Rio de Janeiro-
Formato: dc.format319-324-
Idioma: dc.languageen-
Relação: dc.relationORL-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectLaryngeal cancer-
Palavras-chave: dc.subjectLaryngeal squamous cell carcinoma-
Palavras-chave: dc.subjectp63 expression-
Título: dc.titleExpression profile of p63 in 127 patients with laryngeal squamous cell carcinoma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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