Minor furanocoumarins and coumarins in grapefruit peel oil as inhibitors of human cytochrome P450 3A4

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUSDA-Agricultural Research Service-South Atlantic Area-
Autor(es): dc.creatorCésar, Thaïs B.-
Autor(es): dc.creatorManthey, John A.-
Autor(es): dc.creatorMyung, Kyung-
Data de aceite: dc.date.accessioned2022-08-04T22:01:59Z-
Data de disponibilização: dc.date.available2022-08-04T22:01:59Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2009-09-25-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/np900266m-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/219526-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/219526-
Descrição: dc.descriptionA new cyclic acetal (1) of marmin (6′,7′-dihydroxy-7- geranyloxycoumarin), two new cyclic acetals (5, 6) of 6′,7′- dihydroxybergamottin, and the known compounds marmin (2), 7-geranyloxycoumarin (3), bergamottin (4), and 6′,7′-dihydroxybergamottin (7) were isolated from grapefruit peel oil. All compounds were tested for inhibitory activity against intestinal cytochrome P450 3A4, an enzyme involved in the grapefruit/drug interactions in humans. Coumarins (1-3) exhibited negligible inhibitory activity, while the furanocoumarins (4-7) showed potent in vitro inhibitory activity with IC50 values of 2.42, 0.13, 0.27, and 1.58 μM, respectively.-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences University of São Paulo State, Araraquara-
Descrição: dc.descriptionU.S. Citrus and Subtropical Products Laboratory USDA-Agricultural Research Service-South Atlantic Area, Winter Haven, FL 33881-
Formato: dc.format1702-1704-
Idioma: dc.languageen-
Relação: dc.relationJournal of Natural Products-
???dc.source???: dc.sourceScopus-
Título: dc.titleMinor furanocoumarins and coumarins in grapefruit peel oil as inhibitors of human cytochrome P450 3A4-
Tipo de arquivo: dc.typelivro digital-
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