O transplante de células-tronco hematopoéticas como opção no tratamento de doenças não hematológicas

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUnidade de TCTH-
Autor(es): dc.contributorBiomédico do IMC-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRuiz, Milton A.-
Autor(es): dc.creatorPiron-Ruiz, Lilian-
Autor(es): dc.creatorLago, Mario R.-
Autor(es): dc.creatorMaset, Angelo-
Autor(es): dc.creatorSantos, Adriana B. [UNESP]-
Autor(es): dc.creatorGreco, Oswaldo T.-
Data de aceite: dc.date.accessioned2022-08-04T22:01:58Z-
Data de disponibilização: dc.date.available2022-08-04T22:01:58Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2009-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S1516-84842009005000028-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/219522-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/219522-
Descrição: dc.descriptionIn this report we discuss data and perspectives of hematopoietic stem cell transplantation in non-hematologic diseases. Aspects related to the conditioning regimen and its relationship with toxicity and mortality are also presented. Specific autoimmune diseases are discussed, in particular systemic lupus erythematosus, systemic sclerosis, multiple sclerosis and type 1 diabetes mellitus. The aim of the procedure in autoimmune diseases is immune reprogramming. Apparently this procedure has indications for diseases in which conventional treatments have failed when organ damage is not definitive, but likely to occur if transplantation is not performed. The most promising method appears to be autologous stem cell transplantation with non-myeloablative conditioning regimens to obtain survival that is estimated at more than 50% for all autoimmune diseases, with low toxicity and no mortality related to transplantation. The controversial results of solid tumor treatment and particularities of breast cancer are also presented. Hematopoietic stem cell transplantation is the apparent indication for solid tumors based on intensive treatment with myeloablative doses in order to induce the graft versus tumor effect. The myeloablative conditioning regimens are introduced with the purpose of reducing the toxicity and inducing immunosuppression but the data are insufficient and questionable requiring the introduction of new therapeutic strategies based on cellular and immune therapy.-
Descrição: dc.descriptionFMUSP-SP IMC/HMC, São José do Rio Preto-SP-
Descrição: dc.descriptionUnidade de TCTH, APB-Hospital Infante D. Henrique, São José do Rio Preto-SP-
Descrição: dc.descriptionBiomédico do IMC, São José do Rio Preto-SP-
Descrição: dc.descriptionUnesp, São José do Rio Preto -SP-
Descrição: dc.descriptionDepartamento Científico do IMC, São José do Rio Preto-SP-
Descrição: dc.descriptionUnesp, São José do Rio Preto -SP-
Formato: dc.format68-74-
Idioma: dc.languagept_BR-
Relação: dc.relationRevista Brasileira de Hematologia e Hemoterapia-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAllogeneic-
Palavras-chave: dc.subjectAutoimmune diseases-
Palavras-chave: dc.subjectAutologous-
Palavras-chave: dc.subjectConditioning regimen-
Palavras-chave: dc.subjectHematopoietic stem cell transplantation-
Palavras-chave: dc.subjectSolid tumors-
Título: dc.titleO transplante de células-tronco hematopoéticas como opção no tratamento de doenças não hematológicas-
Título: dc.titleHematopoietic stem cell transplant: A therapeutic option for non-hematologic diseases-
Aparece nas coleções:Repositório Institucional - Unesp

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