T allele of -344C/T polymorphism in aldosterone synthase gene is not associated with resistant hypertension

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorLacchini, Riccardo-
Autor(es): dc.creatorSabha, Maricene-
Autor(es): dc.creatorCoeli, Fernanda B.-
Autor(es): dc.creatorFavero, Fabrício F.-
Autor(es): dc.creatorYugar-Toledo, Juan-
Autor(es): dc.creatorIzidoro-Toledo, Tatiane C.-
Autor(es): dc.creatorSandrim, Valéria C.-
Autor(es): dc.creatorTanus-Santos, José E.-
Autor(es): dc.creatorde Mello, Maricilda P.-
Autor(es): dc.creatorMoreno Jr., Heitor-
Data de aceite: dc.date.accessioned2022-08-04T22:01:57Z-
Data de disponibilização: dc.date.available2022-08-04T22:01:57Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2009-08-12-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/hr.2008.36-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/219513-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/219513-
Descrição: dc.descriptionResistant hypertension (RH) is the maintenance of elevated blood pressure concurrent with the use of three different anti-hypertensive drugs, one of which is a diuretic. The Renin-Angiotensin-Aldosterone System plays a major role in volume-dependent hypertension. Therefore, its components are interesting targets for genetic association studies. This work focused on the -344 C/T polymorphism in the CYP11b2 gene, which encodes aldosterone synthase. This work evaluates the association between T allele and resistance to anti-hypertensive treatment. Genotyping analysis included 88 subjects with RH, 142 who were responsive to anti-hypertensive treatment and 110 subjects as a control group. Plasmatic concentrations of aldosterone, renin and cortisol, carotid intima-media thickness and carotid-femoral pulse wave velocity were assessed in a smaller subset of hypertensive patients. An association was found between T allele and hypertension (P<0.005), but there was no difference in allele frequencies between both hypertensive groups. There was no difference in plasmatic parameters either, in remodeling indicators between the genotypic groups.-
Descrição: dc.descriptionDepartment of Pharmacology Faculty of Medical Sciences State University of Campinas (UNICAMP), Campinas, São Paulo-
Descrição: dc.descriptionHuman Genetics Laboratory, Molecular Biology and Genetics Centre (CBMEG) State University of Campinas (UNICAMP), Campinas, São Paulo-
Descrição: dc.descriptionDepartment of Pharmacology Faculty of Medicine of Ribeirão Preto State University of São Paulo (USP), São Paulo-
Formato: dc.format159-162-
Idioma: dc.languageen-
Relação: dc.relationHypertension Research-
???dc.source???: dc.sourceScopus-
Título: dc.titleT allele of -344C/T polymorphism in aldosterone synthase gene is not associated with resistant hypertension-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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