Triterpenes from maytenus macrocarpa and evaluation of their anti-hiv activity

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Salerno-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorLondon Hospital-
Autor(es): dc.creatorPiacente, Sonia-
Autor(es): dc.creatorDos Santos, Lourdes Campaner [UNESP]-
Autor(es): dc.creatorMahmood, Naheed-
Autor(es): dc.creatorPizza, Cosimo-
Data de aceite: dc.date.accessioned2022-08-04T22:01:48Z-
Data de disponibilização: dc.date.available2022-08-04T22:01:48Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2006-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/1934578x0600101201-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/219466-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/219466-
Descrição: dc.descriptionA set of pentacyclic triterpenes has been isolated from the bark of Maytenus macrocarpa (Celastraceae). It includes two new olean-12-ene derivatives, namely 3β, 22α-dihydroxy-olean-12-en-30-oic acid (1) and 22α-hydroxy-olean-12-en-3-oxo-30-oic acid (2), and the new urs-12-ene derivative 3-(E)-coumaroyluvaol (7), along with 10 known compounds possessing olean-12- ene, urs-12-ene, lupane and friedelane skeletons. The structures have been elucidated by extensive spectroscopic methods including 1D- and 2D-NMR experiments, as well as ESI-MS analysis. All isolated compounds were tested for anti-HIV activity in C8166 cells infected with HIV-1MN. The most active compound was 22α-hydroxy-12-en-3-oxo-29-oic acid (triterpenonic acid A, 4), with an EC50 value of 1 μg/mL and a selectivity index of 35.-
Descrição: dc.descriptionDipartimento di Scienze Farmaceutiche University of Salerno, via Ponte Don Melillo, 84084 Fisciano Salerno-
Descrição: dc.descriptionInstituto de Quimica UNESP, CP335, CEP, 14801-970 Araraquara, SP-
Descrição: dc.descriptionRetroscreen Ltd Academic Virology London Hospital, 64 Turner Street, London E1 2AD-
Descrição: dc.descriptionInstituto de Quimica UNESP, CP335, CEP, 14801-970 Araraquara, SP-
Formato: dc.format1073-1078-
Idioma: dc.languageen-
Relação: dc.relationNatural Product Communications-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnti-HIV activity-
Palavras-chave: dc.subjectCelastraceae-
Palavras-chave: dc.subjectMaytenus macrocarpa-
Palavras-chave: dc.subjectPentacyclic triterpenes-
Título: dc.titleTriterpenes from maytenus macrocarpa and evaluation of their anti-hiv activity-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.