Effect of aging on glucose homeostasis: Accelerated deterioration of β-cell function in individuals with impaired glucose tolerance

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Autor(es): dc.contributorSchool of Medicine-
Autor(es): dc.contributorLudwig-Maximilians-University Munich-
Autor(es): dc.contributorUniversity Medical Center Utrecht-
Autor(es): dc.contributorCarl T. Hayden VA Medical Center-
Autor(es): dc.contributorHenry Dunant Foundation-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorBox MED/CRC-
Autor(es): dc.creatorSzoke, Ervin-
Autor(es): dc.creatorShrayyef, Muhammad Z.-
Autor(es): dc.creatorMessing, Susan-
Autor(es): dc.creatorWoerle, Hans J.-
Autor(es): dc.creatorVan Haeften, Timon W.-
Autor(es): dc.creatorMeyer, Christian-
Autor(es): dc.creatorMltrakou, Asimina-
Autor(es): dc.creatorPimenta, Walkyria-
Autor(es): dc.creatorGerich, John E.-
Data de aceite: dc.date.accessioned2022-08-04T22:01:46Z-
Data de disponibilização: dc.date.available2022-08-04T22:01:46Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2008-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2337/dc07-1443-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/219454-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/219454-
Descrição: dc.descriptionOBJECTIVE -To examine the effect of aging on insulin secretion (first- and second-phase insulin release) and insulin sensitivity in people with normal glucose tolerance (NGT) or impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS- First- and second-phase insulin secretion and insulin sensitivity were assessed in hyperglycemic clamp experiments in 266 individuals with NGT and 130 individuals with IGT, ranging in age from ∼20 to ∼70 years. Changes in β-cell function were compared using the disposition index to adjust for differences in insulin sensitivity. RESULTS -As expected, both phases of insulin release and insulin sensitivity were reduced in individuals with IGT (all P < 0.01). Insulin sensitivity was not independently correlated with age in either group. In people with NGT, the disposition index for first-and second-phase insulin release decreased similarly at a rate of ∼0.7% per year. In people with IGT, the disposition indexes for first-and second-phase insulin release decreased at greater rates (∼2.2 and 1.4% per year, P = 0.002 and 0.009, respectively, vs. NGT), with the decrease in first phase being greater than that of second phase (P = 0.025). CONCLUSIONS -Insulin secretion (both first and second phase) normally decreases at a rate of ∼ 0.7% per year with aging; this decrease in β-cell function is accelerated about two-fold in people with impaired glucose tolerance-first phase to a greater extent than second phase. Finally, aging per se has no effect on insulin sensitivity independent of changes in body composition. © 2008 by the American Diabetes Association.-
Descrição: dc.descriptionDepartment of Medicine University of Rochester School of Medicine, Rochester, NY-
Descrição: dc.descriptionDepartment of Biostatistics and Computational Biology University of Rochester School of Medicine, Rochester, NY-
Descrição: dc.descriptionDepartment of Internal Medicine II Ludwig-Maximilians-University Munich, Munich-
Descrição: dc.descriptionDepartment of Internal Medicine University Medical Center Utrecht, Utrecht-
Descrição: dc.descriptionDepartment of Endocrinology Carl T. Hayden VA Medical Center, Phoenix, AZ-
Descrição: dc.descriptionDiabetes/Metabolism Unit Henry Dunant Foundation, Athens-
Descrição: dc.descriptionDepartment of Clinical Medicine Faculdade de Medicina Botucatu University of São Paulo State, São Paulo-
Descrição: dc.descriptionUniversity of Rochester School of Medicine Box MED/CRC, 601 Elmwood Ave, Rochester, NY 1464-
Formato: dc.format539-543-
Idioma: dc.languageen-
Relação: dc.relationDiabetes Care-
???dc.source???: dc.sourceScopus-
Título: dc.titleEffect of aging on glucose homeostasis: Accelerated deterioration of β-cell function in individuals with impaired glucose tolerance-
Tipo de arquivo: dc.typelivro digital-
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