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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | School of Medicine | - |
Autor(es): dc.contributor | Ludwig-Maximilians-University Munich | - |
Autor(es): dc.contributor | University Medical Center Utrecht | - |
Autor(es): dc.contributor | Carl T. Hayden VA Medical Center | - |
Autor(es): dc.contributor | Henry Dunant Foundation | - |
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.contributor | Box MED/CRC | - |
Autor(es): dc.creator | Szoke, Ervin | - |
Autor(es): dc.creator | Shrayyef, Muhammad Z. | - |
Autor(es): dc.creator | Messing, Susan | - |
Autor(es): dc.creator | Woerle, Hans J. | - |
Autor(es): dc.creator | Van Haeften, Timon W. | - |
Autor(es): dc.creator | Meyer, Christian | - |
Autor(es): dc.creator | Mltrakou, Asimina | - |
Autor(es): dc.creator | Pimenta, Walkyria | - |
Autor(es): dc.creator | Gerich, John E. | - |
Data de aceite: dc.date.accessioned | 2022-08-04T22:01:46Z | - |
Data de disponibilização: dc.date.available | 2022-08-04T22:01:46Z | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2008-03-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.2337/dc07-1443 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/219454 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/219454 | - |
Descrição: dc.description | OBJECTIVE -To examine the effect of aging on insulin secretion (first- and second-phase insulin release) and insulin sensitivity in people with normal glucose tolerance (NGT) or impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS- First- and second-phase insulin secretion and insulin sensitivity were assessed in hyperglycemic clamp experiments in 266 individuals with NGT and 130 individuals with IGT, ranging in age from ∼20 to ∼70 years. Changes in β-cell function were compared using the disposition index to adjust for differences in insulin sensitivity. RESULTS -As expected, both phases of insulin release and insulin sensitivity were reduced in individuals with IGT (all P < 0.01). Insulin sensitivity was not independently correlated with age in either group. In people with NGT, the disposition index for first-and second-phase insulin release decreased similarly at a rate of ∼0.7% per year. In people with IGT, the disposition indexes for first-and second-phase insulin release decreased at greater rates (∼2.2 and 1.4% per year, P = 0.002 and 0.009, respectively, vs. NGT), with the decrease in first phase being greater than that of second phase (P = 0.025). CONCLUSIONS -Insulin secretion (both first and second phase) normally decreases at a rate of ∼ 0.7% per year with aging; this decrease in β-cell function is accelerated about two-fold in people with impaired glucose tolerance-first phase to a greater extent than second phase. Finally, aging per se has no effect on insulin sensitivity independent of changes in body composition. © 2008 by the American Diabetes Association. | - |
Descrição: dc.description | Department of Medicine University of Rochester School of Medicine, Rochester, NY | - |
Descrição: dc.description | Department of Biostatistics and Computational Biology University of Rochester School of Medicine, Rochester, NY | - |
Descrição: dc.description | Department of Internal Medicine II Ludwig-Maximilians-University Munich, Munich | - |
Descrição: dc.description | Department of Internal Medicine University Medical Center Utrecht, Utrecht | - |
Descrição: dc.description | Department of Endocrinology Carl T. Hayden VA Medical Center, Phoenix, AZ | - |
Descrição: dc.description | Diabetes/Metabolism Unit Henry Dunant Foundation, Athens | - |
Descrição: dc.description | Department of Clinical Medicine Faculdade de Medicina Botucatu University of São Paulo State, São Paulo | - |
Descrição: dc.description | University of Rochester School of Medicine Box MED/CRC, 601 Elmwood Ave, Rochester, NY 1464 | - |
Formato: dc.format | 539-543 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Diabetes Care | - |
???dc.source???: dc.source | Scopus | - |
Título: dc.title | Effect of aging on glucose homeostasis: Accelerated deterioration of β-cell function in individuals with impaired glucose tolerance | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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