Determination of gatifloxacin in bulk and tablet preparations by high-performance liquid chromatography

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSalgado, Hérida R. N. [UNESP]-
Autor(es): dc.creatorLopes, Cristiani C. G. O. [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:01:38Z-
Data de disponibilização: dc.date.available2022-08-04T22:01:38Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2006-12-22-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/219404-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/219404-
Descrição: dc.descriptionA sensitive, precise, and specific high-performance liquid chromatographic (HPLC) method was developed for the assay of gatifloxacin (GATX) in raw material and tablets. The method validation parameters yielded good results and included the range, linearity, precision, accuracy, specificity, and recovery. It was also found that the excipients in the commercial tablet preparation did not interfere with the assay. The HPLC separation was carried out by reversed-phase chromatography on a C18 absorbosphere column (250 × 4.6 mm id, 5 μm particle size) with a mobile phase composed of acetic acid 5%-acetonitrile- methanol (70 + 15 + 15, v/v/v) pumped isocratically at a flow rate of 1.0 mL/min. The effluent was monitored at 287 nm. The calibration graph for GATX was linear from 4.0 to 14.0 μg/mL. The interday and intraday precisions (relative standard deviation) were less than 1.05%.-
Descrição: dc.descriptionPrograma de Pós-Graduação em Ciências Farmacêuticas Faculdade de Ciências Farmacêuticas UNESP, Rod. Araraquara-Jaú, km 1, CEP 14801-902, Araraquara, SP-
Descrição: dc.descriptionPrograma de Pós-Graduação em Ciências Farmacêuticas Faculdade de Ciências Farmacêuticas UNESP, Rod. Araraquara-Jaú, km 1, CEP 14801-902, Araraquara, SP-
Formato: dc.format642-645-
Idioma: dc.languageen-
Relação: dc.relationJournal of AOAC International-
???dc.source???: dc.sourceScopus-
Título: dc.titleDetermination of gatifloxacin in bulk and tablet preparations by high-performance liquid chromatography-
Tipo de arquivo: dc.typelivro digital-
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