Determination of lomefloxacin in tablet preparations by liquid chromatography

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorTozo, Greci C. G. [UNESP]-
Autor(es): dc.creatorSalgado, Hérida R. N. [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:01:37Z-
Data de disponibilização: dc.date.available2022-08-04T22:01:37Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2006-09-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/219403-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/219403-
Descrição: dc.descriptionA sensitive, precise, and specific high-performance liquid chromatography (HPLC) method was developed for the assay of lomefloxacin (LFLX) in raw material and tablet preparations. The method validation parameters yielded good results and included the range, linearity, precision, accuracy, specificity, and recovery. It was also found that the excipients in the commercial tablet preparation did not interfere with the assay. The HPLC separation was performed on a reversed-phase Phenomenex C18 column (150 × 4.6 mm id, 5 μ particle size) with a mobile phase composed of 1% acetic acid-acetonitrile- methanol (70 + 15 + 15, v/v/v), pumped isocratically at a flow rate of 1.0 mL/min. The effluent was monitored at 280 nm. The calibration graph for LFLX was linear from 2.0 to 7.0 mg/mL. The interday and intraday precisions (relative standard deviation) were less than 1.0%. The method was applied for the quality control of commercial LFLX tablets to quantitate the drug.-
Descrição: dc.descriptionFaculdade de Ciências Farmacêuticas Programa de Pós-Graduaçâo em Ciências Farmacêuticas UNESP, Rod. Araraquara-Jaú, km 1, CEP 14801-902, Araraquara, SP-
Descrição: dc.descriptionFaculdade de Ciências Farmacêuticas Programa de Pós-Graduaçâo em Ciências Farmacêuticas UNESP, Rod. Araraquara-Jaú, km 1, CEP 14801-902, Araraquara, SP-
Formato: dc.format1305-1308-
Idioma: dc.languageen-
Relação: dc.relationJournal of AOAC International-
???dc.source???: dc.sourceScopus-
Título: dc.titleDetermination of lomefloxacin in tablet preparations by liquid chromatography-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.