Hyperglycemia and nocturnal systolic blood pressure are associated with left ventricular hypertrophy and diastolic dysfunction in hypertensive diabetic patients

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Autor(es): dc.contributorUniversidade Federal do Pará (UFPA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.creatorFelício, João S.-
Autor(es): dc.creatorPacheco, Juliana T.-
Autor(es): dc.creatorFerreira, Sandra R. [UNESP]-
Autor(es): dc.creatorPlavnik, Frida-
Autor(es): dc.creatorMoisés, Valdir A.-
Autor(es): dc.creatorKohlmann Jr., Oswaldo-
Autor(es): dc.creatorRibeiro, Artur B.-
Autor(es): dc.creatorZenella, Maria T.-
Data de aceite: dc.date.accessioned2022-08-04T22:01:37Z-
Data de disponibilização: dc.date.available2022-08-04T22:01:37Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2006-09-12-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/1475-2840-5-19-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/219402-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/219402-
Descrição: dc.descriptionBackground: The aim of this study was to determine if hypertensive type 2 diabetic patients, when compared to patients with essential hypertension have an increased left ventricular mass index (LVMI) and a worse diastolic function, and if this fact would be related to 24-h pressoric levels changes. Methods: Ninety-one hypertensive patients with type 2 diabetes mellitus (DM) (group-1 [G1]), 59 essential hypertensive patients (group-2 [G2]) and 26 healthy controls (group-3 [G3]) were submitted to 24-h Ambulatory Blood Pressure Monitoring (ABPM) and echocardiography (ECHO) with Doppler. We calculated an average of fasting blood glucose (AFBG) values of G1 from the previous 4.2 years and a glycemic control index (GCI) (percentual of FBG above 200 mg/dl). Results: G1 and G2 did not differ on average of diurnal systolic and diastolic BP. However, G1 presented worse diastolic function and a higher average of nocturnal systolic BP (NSBP) and LVMI (NSBP = 132 ± 18 vs 124 ± 14 mmHg; P < 0.05 and LVMI = 103 ± 27 vs 89 ± 17 g/m2; P < 0.05, respectively). In G1, LVMI correlated with NSBP (r = 0.37; P < 0.001) and GCI (r = 0.29; P < 0.05) while NSBP correlated with GCI (r = 0.27; P < 0.05) and AFBG (r = 0.30; P < 0.01). When G1 was divided in tertiles according to NSBP, the subgroup with NSBP≥140 mmHg showed a higher risk of LVH. Diabetics with NSBP≥140 mmHg and AFBG>165 mg/dl showed an additional risk of LVH (P < 0.05; odds ratio = 11). In multivariate regression, both GCI and NSBP were independent predictors of LVMI in G1. Conclusion: This study suggests that hyperglycemia and higher NSBP levels should be responsible for an increased prevalence of LVH in hypertensive patients with Type 2 DM. © 2006 Felicio et al; licensee BioMed Central Ltd.-
Descrição: dc.descriptionEndocrinology Division Universidade Federal do Pará, Belém-
Descrição: dc.descriptionEpidemiology Division Universidade Estadual de São Paulo, São Paulo-
Descrição: dc.descriptionNephrology Division Endocrinology Division UNIFESP, São Paulo-
Descrição: dc.descriptionEpidemiology Division Universidade Estadual de São Paulo, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationCardiovascular Diabetology-
???dc.source???: dc.sourceScopus-
Título: dc.titleHyperglycemia and nocturnal systolic blood pressure are associated with left ventricular hypertrophy and diastolic dysfunction in hypertensive diabetic patients-
Tipo de arquivo: dc.typelivro digital-
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