Failure of hypertonic glucose supplementation to improve whole-body protein metabolism in fed trauma patients

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSchelp, A. O. [UNESP]-
Autor(es): dc.creatorTeixeira, U. A. [UNESP]-
Autor(es): dc.creatorTsuji, H. [UNESP]-
Autor(es): dc.creatorAngeleli, A. Y.O. [UNESP]-
Autor(es): dc.creatorBicudo, M. H. [UNESP]-
Autor(es): dc.creatorBurini, R. C. [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:01:37Z-
Data de disponibilização: dc.date.available2022-08-04T22:01:37Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued1996-12-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/219400-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/219400-
Descrição: dc.descriptionThe beneficial effect of a high glucose intake for reducing the protein catabolism of trauma patients was investigated in 12 male (21-29 yrs old) patients with trauma, 6 with closed-head injury (HT) Glasgow score 4-6 and 6 with noncranial politrauma (PT), ISS 35-45. The study was undertaken 2-9 days after injury and extended for three consecutive periods (M1, M2 and M3) of 3-days each with the patients receiving enterally a complete liquid diet of 1.9 g protein and 47 kcal/kg/day. During the M2 period, the patients also received an i.v. hypertonic glucose supplement of 17.6 kcal/kg/day. Blood samples were collected thoughout the study for hormone (insulin, C-peptide, glucagon, cortisol and catecholamines) and glucose assays, and urine for whole-body protein metabolism analysis (N-balance and 15N-glycine kinetics). Following the M2 period, the patients, mainly PT, manifested an 11-20 mg/dl increase in plasma glucose without glucosuria, as well as increasing in insulin and Cpeptide levels. Also, the N-balance continued negative without any significant changes in 15N-kinetics. Thus, the present data does not support the assumption of a beneficial effect from glucose supplementation on whole-body protein metabolism in fed trauma patients.-
Descrição: dc.descriptionUNESP Medical SchooL, Botucatu, SP, 18618-000-
Descrição: dc.descriptionUNESP Medical SchooL, Botucatu, SP, 18618-000-
Idioma: dc.languageen-
Relação: dc.relationFASEB Journal-
???dc.source???: dc.sourceScopus-
Título: dc.titleFailure of hypertonic glucose supplementation to improve whole-body protein metabolism in fed trauma patients-
Tipo de arquivo: dc.typelivro digital-
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