Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Carl T. Hayden VA Medical Center | - |
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.contributor | Ludwig-Maximilians University of Munich | - |
Autor(es): dc.contributor | University Medical Center Utrecht | - |
Autor(es): dc.contributor | University of Rochester School of Medicine | - |
Autor(es): dc.contributor | Henry Dunant Foundation | - |
Autor(es): dc.creator | Meyer, Christian | - |
Autor(es): dc.creator | Pimenta, Walkyria | - |
Autor(es): dc.creator | Woerle, Hans J. | - |
Autor(es): dc.creator | Van Haeften, Timon | - |
Autor(es): dc.creator | Szoke, Ervin | - |
Autor(es): dc.creator | Mitrakou, Asimina | - |
Autor(es): dc.creator | Gerich, John | - |
Data de aceite: dc.date.accessioned | 2022-08-04T22:01:36Z | - |
Data de disponibilização: dc.date.available | 2022-08-04T22:01:36Z | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2006-08-07 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.2337/dc06-0438 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/219396 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/219396 | - |
Descrição: dc.description | OBJECTIVE - To compare the pathophysiology of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) in a more comprehensive and standardized fashion than has hitherto been done. RESEARCH DESIGN AND METHODS - We studied 21 individuals with isolated IFG (IFG/normal glucose tolerance [NGT]), 61 individuals with isolated IGT (normal fasting glucose [NFG]/IGT), and 240 healthy control subjects (NFG/NGT) by hyperglycemic clamps to determine first- and second-phase insulin release and insulin sensitivity. Homeostasis model assessment (HOMA) indexes of β-cell function (HOMA-%B) and insulin resistance (HOMA-IR) were calculated from fasting plasma insulin and glucose concentrations. RESULTS - Compared with NFG/NGT, IFG/NGT had similar fasting insulin concentrations despite hyperglycemia; therefore, HOMA-IR was increased ∼30% (P < 0.05), but clampdetermined insulin sensitivity was normal (P > 0.8). HOMA-%B and first-phase insulin responses were reduced ∼35% (P < 0.002) and ∼30% (P < 0.02), respectively, but second-phase insulin responses were normal (P > 0.5). NFG/IGT had normal HOMA-IR but ∼15% decreased clamp-determined insulin sensitivity (P < 0.03). Furthermore, HOMA-%B was normal but both first-phase (P < 0.0003) and second-phase (P < 0.0001) insulin responses were reduced ∼30%. IFG/NGT differed from NFG/IGT by having ∼40% lower HOMA-%B (P < 0.012) and ∼50% greater second-phase insulin responses (P < 0.005). CONCLUSIONS - Since first-phase insulin responses were similarly reduced in IFG/NGT and NFG/IGT, we conclude that IFG is due to impaired basal insulin secretion and preferential resistance of glucose production to suppression by insulin, as reflected by fasting hyperglycemia despite normal plasma insulin concentrations and increased HOMA-IR, whereas IGT mainly results from reduced second-phase insulin release and peripheral insulin resistance, as reflected by reduced clamp-determined insulin sensitivity. © 2006 by the American Diabetes Association. | - |
Descrição: dc.description | Department of Endocrinology Carl T. Hayden VA Medical Center, Phoenix, AZ | - |
Descrição: dc.description | Department of Clinical Medicine Faculdade de Medicina Botucatu University of Sao Paulo State, Sao Paulo | - |
Descrição: dc.description | Department of Internal Medicine II Ludwig-Maximilians University of Munich, Munich | - |
Descrição: dc.description | Department of Internal Medicine University Medical Center Utrecht, Utrecht | - |
Descrição: dc.description | Department of Medicine University of Rochester School of Medicine, Rochester, NY | - |
Descrição: dc.description | Diabetes/Metabolism Unit Henry Dunant Foundation, Athens | - |
Descrição: dc.description | Carl T. Hayden VA Medical Center, 650 East Indian School Rd., Phoenix, AZ 85012 | - |
Formato: dc.format | 1909-1914 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Diabetes Care | - |
???dc.source???: dc.source | Scopus | - |
Título: dc.title | Different mechanisms for impaired fasting glucose and impaired postprandial glucose tolerance in humans | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: