Assessment of staging, prognosis and mortality of colorectal cancer by tumor markers: receptor erbB-2 and cadherins.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorJesus, Eliane C [UNESP]-
Autor(es): dc.creatorMatos, Delcio [UNESP]-
Autor(es): dc.creatorArtigiani, Ricardo [UNESP]-
Autor(es): dc.creatorWaitzberg, Angela F L [UNESP]-
Autor(es): dc.creatorGoldenberg, Alberto [UNESP]-
Autor(es): dc.creatorSaad, Sarhan Sydney [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:01:36Z-
Data de disponibilização: dc.date.available2022-08-04T22:01:36Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2005-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/s0102-86502005000600005-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/219394-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/219394-
Descrição: dc.descriptionPURPOSE: To evaluate the prognostic significance and correlation with staging and degree of cell differentiation of the tumoral expression of the proteins c-erbB-2 and E-cadherin, in patients with colorectal adenocarcinoma. METHODS: The study included 117 patients with an average age of 63.1 years and an average follow-up duration of 28.1 months. The disease-free interval, survival, incidence of recurrence and specific mortality were evaluated. c-erbB-2 anti-oncoprotein antibodies (Dako) were utilized via the streptavidin-biotin technique. Samples were considered to be positive for c-erbB-2 if 10% or more of the tumor cell membranes were stained.The anti-E-cadherin antibodies (Dako), evaluated this protein and is considered positive, if 50% or more of the cell membranes were stained. Statistical analysis was performed using Pearson's chi-squared test, Fisher's exact test, Kaplan-Meier's estimator, the log-rank test and Wilcoxon's test (Breslow version), setting the level of statistical significance at 5% (p<0.05). RESULTS: 52 of 108 patients studied for c-erbB-2 were positive (48.1%), 47 of 93 patients studied for E-cadherin were negative (50.5%). These data do not express any correlation with TNM (tumor, node and metastasis) staging and the degree of cell differentiation or with the tumor recurrence rate. The disease-free interval among patients who were positive for c-erbB-2 and negative for E-cadherin was 68.0 months and did not differ from those with c-erbB-2 negative and E-cadherin positive (55.0 months--p = 0.5510). The average survival among patients positive for c-erbB-2 and negative for E-cadherin was 75 months without statistical significance difference with the other group (61 months--p = 0.5256). Specific mortality occurred in 20.0% of the cases and did not correlate with the expression of c-erbB-2 (p=0.446), E-cadherin (p=0.883). CONCLUSION: The tumoral expression of c-erbB-2 and E-cadherin did not demonstrate a correlation with the staging and degree of cell differentiation, and it did not present prognostic value regarding disease recurrence, disease-free interval, survival and specific mortality among patients with colorectal adenocarcinoma.-
Descrição: dc.descriptionDivision of Gastrointestinal Surgery Federal University of São Paulo (UNESP) Escola Paulista de Medicina-
Descrição: dc.descriptionDivision of Gastrointestinal Surgery Federal University of São Paulo (UNESP) Escola Paulista de Medicina-
Formato: dc.format422-427-
Idioma: dc.languageen-
Relação: dc.relationActa cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia-
???dc.source???: dc.sourceScopus-
Título: dc.titleAssessment of staging, prognosis and mortality of colorectal cancer by tumor markers: receptor erbB-2 and cadherins.-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.