Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue: Type A with a high prevalence of deletions within the latent membrane protein gene

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorCity of Hope National Medical Center-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorChen, Wen-Gang-
Autor(es): dc.creatorChen, Yuan-Yuan-
Autor(es): dc.creatorBacchi, Maura M.-
Autor(es): dc.creatorBacchi, Carlos E.-
Autor(es): dc.creatorAlvarenga, Marcelo-
Autor(es): dc.creatorWeiss, Lawrence M.-
Data de aceite: dc.date.accessioned2022-08-04T22:01:00Z-
Data de disponibilização: dc.date.available2022-08-04T22:01:00Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued1996-01-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/219189-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/219189-
Descrição: dc.descriptionBoth Epstein-Barr virus (EBV) types A and B are found in endemic Burkitt's lymphoma (BL) occurring in equatorial Africa. We studied 17 cases of Brazilian BL previously demonstrated to he EBV-positive to determine the EBV type as well as the presence of a characteristic 30 bp deletion within the 3' end of the latent membrane protein-1 (LMP-1) gene that may be important to the pathogenesis of several EBV-associated neoplasms. All cases in which the age was known were children. We found type A EBV in 13 of 14 (93%) evaluable cases, and type B in one case. The LMP-1 deletion was found in 12 of 15 (80%) evaluable cases, including the one case of type B EBV, and a similar high prevalence (59%) of the deletion was detected in EBV-positive normal and reactive lymphoid tissues from individuals from the same geographic region. The high proportion of cases associated with type A EBV suggests that immunodeficiency is not an important factor in the pathogenesis of Brazilian BL, in contrast to endemic African BL. The presence of the LMP-1 deletion in a high prevalence in the normal population in this region is unexplained.-
Descrição: dc.descriptionDepartments of Pathology City of Hope National Medical Center, Duarte, CA-
Descrição: dc.descriptionState University of Sao Paulo, Botucatu-
Descrição: dc.descriptionUniversity of Campinas (UNICAMP), Campinas, Sao Paulo-
Descrição: dc.descriptionDivision of Pathology City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010-
Formato: dc.format17-23-
Idioma: dc.languageen-
Relação: dc.relationAmerican Journal of Pathology-
???dc.source???: dc.sourceScopus-
Título: dc.titleGenotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue: Type A with a high prevalence of deletions within the latent membrane protein gene-
Tipo de arquivo: dc.typelivro digital-
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