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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | City of Hope National Medical Center | - |
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.contributor | Universidade Estadual de Campinas (UNICAMP) | - |
Autor(es): dc.creator | Chen, Wen-Gang | - |
Autor(es): dc.creator | Chen, Yuan-Yuan | - |
Autor(es): dc.creator | Bacchi, Maura M. | - |
Autor(es): dc.creator | Bacchi, Carlos E. | - |
Autor(es): dc.creator | Alvarenga, Marcelo | - |
Autor(es): dc.creator | Weiss, Lawrence M. | - |
Data de aceite: dc.date.accessioned | 2022-08-04T22:01:00Z | - |
Data de disponibilização: dc.date.available | 2022-08-04T22:01:00Z | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 1996-01-01 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/219189 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/219189 | - |
Descrição: dc.description | Both Epstein-Barr virus (EBV) types A and B are found in endemic Burkitt's lymphoma (BL) occurring in equatorial Africa. We studied 17 cases of Brazilian BL previously demonstrated to he EBV-positive to determine the EBV type as well as the presence of a characteristic 30 bp deletion within the 3' end of the latent membrane protein-1 (LMP-1) gene that may be important to the pathogenesis of several EBV-associated neoplasms. All cases in which the age was known were children. We found type A EBV in 13 of 14 (93%) evaluable cases, and type B in one case. The LMP-1 deletion was found in 12 of 15 (80%) evaluable cases, including the one case of type B EBV, and a similar high prevalence (59%) of the deletion was detected in EBV-positive normal and reactive lymphoid tissues from individuals from the same geographic region. The high proportion of cases associated with type A EBV suggests that immunodeficiency is not an important factor in the pathogenesis of Brazilian BL, in contrast to endemic African BL. The presence of the LMP-1 deletion in a high prevalence in the normal population in this region is unexplained. | - |
Descrição: dc.description | Departments of Pathology City of Hope National Medical Center, Duarte, CA | - |
Descrição: dc.description | State University of Sao Paulo, Botucatu | - |
Descrição: dc.description | University of Campinas (UNICAMP), Campinas, Sao Paulo | - |
Descrição: dc.description | Division of Pathology City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010 | - |
Formato: dc.format | 17-23 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | American Journal of Pathology | - |
???dc.source???: dc.source | Scopus | - |
Título: dc.title | Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue: Type A with a high prevalence of deletions within the latent membrane protein gene | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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