A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorSao Francisco Univ-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRocha, Mackson Martins-
Autor(es): dc.creatorDariva, Isabela-
Autor(es): dc.creatorZornoff, Gabriela Comelli-
Autor(es): dc.creatorDe Laurentis, Giovanna Sanches-
Autor(es): dc.creatorMendes, Giulia Carli-
Autor(es): dc.creatorSantana, Maycon Giovani-
Autor(es): dc.creatorMiguel, Guilherme Chohfi de-
Autor(es): dc.creatorFerreira, Rui Seabra [UNESP]-
Autor(es): dc.creatorSciani, Juliana Mozer-
Autor(es): dc.creatorPriolli, Denise Goncalves-
Data de aceite: dc.date.accessioned2022-08-04T21:59:24Z-
Data de disponibilização: dc.date.available2022-08-04T21:59:24Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-03-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1678-9199-JVATITD-2021-0067-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/218845-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/218845-
Descrição: dc.descriptionBackground: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis. Herein, we propose an approach based on intrametastatic melittin injection to treat bone metastases in colorectal cancer. Methods: Following the characterization of melittin and antiproliferative tests in vitro, a single dose was injected through intrametastatic route into the mouse bone metastasis model. Following treatment, metastasis growth was evaluated. Results: A single dose of melittin was able to inhibit metastasis growth. Histological analysis showed necrosis and inflammatory processes in melittin-treated metastasis. Except by mild weight loss, no other systemic effects were observed. Conclusion: Our data suggest that melittin might be a promising agent for the future development of treatment strategies aiming to reduce the metastasis skeletal-related impact in colorectal cancer patients with bone metastasis.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSao Francisco Univ, Multidisciplinary Lab, Postgrad Program Hlth Sci, Braganca Paulista, SP, Brazil-
Descrição: dc.descriptionSao Francisco Univ, Med Sch, Braganca Paulista, SP, Brazil-
Descrição: dc.descriptionSao Francisco Univ, Nursing Sch, Braganca Paulista, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Ctr Studies Venoms & Venomous Anim CEVAP, Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Ctr Studies Venoms & Venomous Anim CEVAP, Botucatu, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2018/21471-5-
Formato: dc.format10-
Idioma: dc.languageen-
Publicador: dc.publisherCevap-sao Paulo State Univ-unesp-
Relação: dc.relationJournal Of Venomous Animals And Toxins Including Tropical Diseases-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectBone metastasis-
Palavras-chave: dc.subjectMelittin-
Palavras-chave: dc.subjectIntratumoral injection-
Palavras-chave: dc.subjectColorectal neoplasms-
Palavras-chave: dc.subjectBee venom-
Título: dc.titleA new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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