Heart failure as an adverse effect of infliximab for Crohn's disease: A case report and review of the literature

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorClin Univ Los Andes-
Autor(es): dc.creatorGrillo, Thais Gagno [UNESP]-
Autor(es): dc.creatorAlmeida, Luciana Rocha [UNESP]-
Autor(es): dc.creatorBeraldo, Rodrigo Fedatto [UNESP]-
Autor(es): dc.creatorMarcondes, Mariana Barros [UNESP]-
Autor(es): dc.creatorRios Queiroz, Diego Aparecido [UNESP]-
Autor(es): dc.creatorSilva, Daniel Luiz da [UNESP]-
Autor(es): dc.creatorQuera, Rodrigo-
Autor(es): dc.creatorBaima, Julio Pinheiro [UNESP]-
Autor(es): dc.creatorSaad-Hossne, Rogerio [UNESP]-
Autor(es): dc.creatorSassaki, Ligia Yukie [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T21:59:15Z-
Data de disponibilização: dc.date.available2022-08-04T21:59:15Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-11-25-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1299841/wjcc/v.i31.10382-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/218795-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/218795-
Descrição: dc.descriptionBACKGROUND Anti-tumor necrosis factor agents were the first biologic therapy approved for the management of Crohn's disease (CD). Heart failure (HF) is a rare but potential adverse effect of these medications. The objective of this report is to describe a patient- with CD who developed HF after the use of infliximab. CASE SUMMARY A 50-year-old woman with a history of hypertension and diabetes presented with abdominal pain, diarrhea, and weight loss. Colonoscopy and enterotomography showed ulcerations, areas of stenosis and dilation in the terminal ileum, and thickening of the intestinal wall. The patient underwent ileocolectomy and the surgical specimen confirmed the diagnosis of stenosing CD. The patient started inflixirnab and azathioprine treatment to prevent post -surgical recurrence. At 6 mo after initiating infliximab therapy, the patient complained of dyspnea, Or tho pima, and paroxysmal nocturnal dyspnea that gradually worsened. Echocardiography revealed hiventricular dysfunction, moderate cardiac insufficiency, an ejection fraction of 36%, and moderate pericardial effusion, consistent with HF. The cardiac disease was considered an infliximab adverse effect and the drug was discontinued. The patient received treatment with diuretics for HF and showed improvement of symptoms and cardiac function. Currently, the patient is using anti -in erleukin for CD and is asymptoma CONCLUSION This reported case supports the need to investigate risk factors for HF in inflammatory bowel disease patients and to consider the risk -benefit of introducing infliximab therapy in such patients presenting with HF risk factors.-
Descrição: dc.descriptionSao Paulo State Univ Unesp, Med Sch, Dept Internal Med, Av Prof Mario Rubens Guimaraes Montenegro S-N, BR-18618687 Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ Unesp, Med Sch, Dept Pathol, BR-18618687 Botucatu, SP, Brazil-
Descrição: dc.descriptionClin Univ Los Andes, Inflammatory Bowel Dis Program, Digest Dis Ctr, Santiago 7550000, Chile-
Descrição: dc.descriptionSao Paulo State Univ Unesp, Med Sch, Dept Internal Med, Av Prof Mario Rubens Guimaraes Montenegro S-N, BR-18618687 Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ Unesp, Med Sch, Dept Pathol, BR-18618687 Botucatu, SP, Brazil-
Formato: dc.format10382-10391-
Idioma: dc.languageen-
Publicador: dc.publisherBaishideng Publishing Group Inc-
Relação: dc.relationWorld Journal Of Clinical Cases-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectHeart failure-
Palavras-chave: dc.subjectinfliximab-
Palavras-chave: dc.subjectAnti tumor necrosis factor therapy-
Palavras-chave: dc.subjectCrohn's disease-
Palavras-chave: dc.subjectinflammatory bowel disease-
Palavras-chave: dc.subjectCase report-
Título: dc.titleHeart failure as an adverse effect of infliximab for Crohn's disease: A case report and review of the literature-
Aparece nas coleções:Repositório Institucional - Unesp

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