Metabolic changes in female rats exposed to intrauterine hyperglycemia and postweaning consumption of high-fat diet

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorFed Univ Maranhao UFMA-
Autor(es): dc.creatorPaula, Veronyca Goncalves [UNESP]-
Autor(es): dc.creatorSinzato, Yuri Karen [UNESP]-
Autor(es): dc.creatorMoraes-Souza, Rafaianne Queiroz de [UNESP]-
Autor(es): dc.creatorSoares, Thaigra Sousa [UNESP]-
Autor(es): dc.creatorGallego Souza, Franciane Quintanilha [UNESP]-
Autor(es): dc.creatorKarki, Barshana [UNESP]-
Autor(es): dc.creatorAndrade Paes, Antonio Marcus de-
Autor(es): dc.creatorCorrente, Jose Eduardo [UNESP]-
Autor(es): dc.creatorDamasceno, Debora Cristina [UNESP]-
Autor(es): dc.creatorVolpato, Gustavo Tadeu-
Data de aceite: dc.date.accessioned2022-08-04T21:59:11Z-
Data de disponibilização: dc.date.available2022-08-04T21:59:11Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-10-19-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/biolre/ioab195-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/218771-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/218771-
Descrição: dc.descriptionWe evaluated the influence of the hyperglycemic intrauterine environment and postweaning consumption of a high-fat diet (HFD) on the glycemia, insulin, lipid, and immunological profile of rat offspring in adulthood. Female rats received citrate buffer (Control-C) or Streptozotocin (a beta cell-cytotoxic drug to induce diabetes-D) on postnatal day 5. In adulthood, these rats were mated to obtain female offspring, who were fed a standard diet (SD) or HFD from weaning to adulthood (n = 10 rats/group). OC/SD and OC/HFD represent female offspring of control mothers and received SD or HFD, respectively; OD/SD and OD/HFD represent female offspring of diabetic mothers and received SD or HFD, respectively. At adulthood, the oral glucose tolerance test (OGTT) was performed and, next, the rats were anesthetized and euthanized. Pancreas was collected and analyzed, and adipose tissue was weighted. Blood samples were collected to determine biochemical and immunological profiles. The food intake was lower in HFD-fed rats and visceral fat weight was increased in the OD/HFD group. OC/HFD, OD/SD, and OD/HFD groups presented glucose intolerance and lower insulin secretion during OGTT. An impaired pancreatic beta-cell function was shown in the adult offspring of diabetic rats, regardless of diet. Interleukin (IL)-6 and IL-10 concentrations were lower in the OD/HFD group and associated to a low-grade inflammatory condition. The fetal programming was responsible for impaired beta cell function in experimental animals. The association of maternal diabetes and postweaning HFD are responsible for greater glucose intolerance, impaired insulin secretion and immunological change. Summary sentence Summary Sentence The association of maternal diabetes and postweaning HFD causes glucose intolerance due to beta-cell disarrangement and impaired insulin secretion, and immunological changes in adult offspring.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSJo Paulo State Univ UNESP, Botucatu Med Sch, Lab Expt Res Gynecol & Obstet, Tocogynecol Postgrad Course, Botucatu, SP, Brazil-
Descrição: dc.descriptionFed Univ Mato Grosso UFMT, Inst Biol & Hlth Sci, Lab Syst Physiol & Reprod Toxicol, Barra Do Garcas, MT, Brazil-
Descrição: dc.descriptionFed Univ Maranhao UFMA, Dept Physiol Sci, Lab Expt Physiol, Sao Luis, MA, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista UNESP, Botucatu Med Sch, Res Support Off, Botucatu, SP, Brazil-
Descrição: dc.descriptionSJo Paulo State Univ UNESP, Botucatu Med Sch, Lab Expt Res Gynecol & Obstet, Tocogynecol Postgrad Course, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista UNESP, Botucatu Med Sch, Res Support Off, Botucatu, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2016/25207-5-
Formato: dc.format200-212-
Idioma: dc.languageen-
Publicador: dc.publisherOxford Univ Press Inc-
Relação: dc.relationBiology Of Reproduction-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectfetal programming-
Palavras-chave: dc.subjecthigh-fat diet-
Palavras-chave: dc.subjectdiabetes-
Palavras-chave: dc.subjectrat-
Título: dc.titleMetabolic changes in female rats exposed to intrauterine hyperglycemia and postweaning consumption of high-fat diet-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.