Characteristics associated with Lactobacillus iners-dominated vaginal microbiota

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniv Maryland-
Autor(es): dc.contributorUniv Fed Parana-
Autor(es): dc.creatorNovak, Juliano [UNESP]-
Autor(es): dc.creatorRavel, Jacques-
Autor(es): dc.creatorMa, Bing-
Autor(es): dc.creatorTafner Ferreira, Carolina Sanita [UNESP]-
Autor(es): dc.creatorTristao, Andrea da Rocha [UNESP]-
Autor(es): dc.creatorSilva, Marcia Guimaraes [UNESP]-
Autor(es): dc.creatorMarconi, Camila [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T21:59:02Z-
Data de disponibilização: dc.date.available2022-08-04T21:59:02Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-09-08-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1136/sextrans-2020-054824-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/218726-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/218726-
Descrição: dc.descriptionObjective The protective role of Lactobacillus iners in the vaginal microbiota has been questioned. Recent studies have shown that L. iners is the dominating taxon in a large subset of women worldwide. The aim of this study was to identify sociodemographic, behavioural and clinical variables associated with L. iners-dominated community state type (CST) III in Brazilian women of reproductive age. Participants and methods This study leveraged microbiota compositional data generated by sequencing of the V3-V4 16S rRNA gene from vaginal samples collected from 442 participants enrolled in a previous cross-sectional study that included 609 women in five geographical regions of Brazil. A total of 167 (27.4%) participants were excluded from the current study as they did not present a Lactobacillus-dominated vaginal microbiota. Data on sociodemographic and behavioural characteristics of the study population were obtained through face-to-face interviews. Participants were assigned to two study groups: those with L. iners-dominated CST III (n=222) and those with three distinct CSTs (I, II or V) dominated by another Lactobacillus spp. (n=220). Logistic regression analysis using a stepwise method was performed to test association between CST III and participants' characteristics, considering their OR and 95% CIs. Results Among the population characteristics assessed, L. iners-dominated CST III was independently associated with having two or more sexual partners (OR 3.27; 95% CI 1.50 to 7.11) and microscopic detection of Candida sp. on vaginal smears (OR 2.24; 95% CI 1.02 to 4.89). Other characteristics were inversely associated with CST III, including condom use (OR 0.59; 95% CI 0.38 to 0.91), higher educational level (OR 0.61; 95% CI 0.41 to 0.91) and diet containing milk/dairy intake (OR 0.43; 95% CI 0.20 to 0.90). Conclusion Unprotected sex practices, number of sexual partners and lower educational levels may be useful for identifying women with L. iners-dominated microbiota and its suboptimal protective properties. L. iners microbiota does not seem to provide optimal protection against Candida sp. colonisation, warranting further investigation.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSao Paulo State Univ, Med Sch, Dept Pathol, UNESP, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Maryland, Dept Microbiol & Immunol, Baltimore, MD 21201 USA-
Descrição: dc.descriptionUniv Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA-
Descrição: dc.descriptionSao Paulo State Univ, Med Sch, Dept Gynecol & Obstet, UNESP, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Fed Parana, Dept Basic Pathol, Curitiba, Parana, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Med Sch, Dept Pathol, UNESP, Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Med Sch, Dept Gynecol & Obstet, UNESP, Botucatu, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2012/16800-3-
Descrição: dc.descriptionCAPES: 1680048-
Formato: dc.format7-
Idioma: dc.languageen-
Publicador: dc.publisherBmj Publishing Group-
Relação: dc.relationSexually Transmitted Infections-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectbacterial infections-
Palavras-chave: dc.subjectvaginosis-
Palavras-chave: dc.subjectbacterial-
Palavras-chave: dc.subjectmolecular biology-
Palavras-chave: dc.subjectvaginal smears-
Palavras-chave: dc.subjectsexual behaviour-
Título: dc.titleCharacteristics associated with Lactobacillus iners-dominated vaginal microbiota-
Tipo de arquivo: dc.typelivro digital-
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