Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (UNESP) | - |
Autor(es): dc.contributor | Univ Maryland | - |
Autor(es): dc.contributor | Univ Fed Parana | - |
Autor(es): dc.creator | Novak, Juliano [UNESP] | - |
Autor(es): dc.creator | Ravel, Jacques | - |
Autor(es): dc.creator | Ma, Bing | - |
Autor(es): dc.creator | Tafner Ferreira, Carolina Sanita [UNESP] | - |
Autor(es): dc.creator | Tristao, Andrea da Rocha [UNESP] | - |
Autor(es): dc.creator | Silva, Marcia Guimaraes [UNESP] | - |
Autor(es): dc.creator | Marconi, Camila [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-08-04T21:59:02Z | - |
Data de disponibilização: dc.date.available | 2022-08-04T21:59:02Z | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2021-09-08 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1136/sextrans-2020-054824 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/218726 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/218726 | - |
Descrição: dc.description | Objective The protective role of Lactobacillus iners in the vaginal microbiota has been questioned. Recent studies have shown that L. iners is the dominating taxon in a large subset of women worldwide. The aim of this study was to identify sociodemographic, behavioural and clinical variables associated with L. iners-dominated community state type (CST) III in Brazilian women of reproductive age. Participants and methods This study leveraged microbiota compositional data generated by sequencing of the V3-V4 16S rRNA gene from vaginal samples collected from 442 participants enrolled in a previous cross-sectional study that included 609 women in five geographical regions of Brazil. A total of 167 (27.4%) participants were excluded from the current study as they did not present a Lactobacillus-dominated vaginal microbiota. Data on sociodemographic and behavioural characteristics of the study population were obtained through face-to-face interviews. Participants were assigned to two study groups: those with L. iners-dominated CST III (n=222) and those with three distinct CSTs (I, II or V) dominated by another Lactobacillus spp. (n=220). Logistic regression analysis using a stepwise method was performed to test association between CST III and participants' characteristics, considering their OR and 95% CIs. Results Among the population characteristics assessed, L. iners-dominated CST III was independently associated with having two or more sexual partners (OR 3.27; 95% CI 1.50 to 7.11) and microscopic detection of Candida sp. on vaginal smears (OR 2.24; 95% CI 1.02 to 4.89). Other characteristics were inversely associated with CST III, including condom use (OR 0.59; 95% CI 0.38 to 0.91), higher educational level (OR 0.61; 95% CI 0.41 to 0.91) and diet containing milk/dairy intake (OR 0.43; 95% CI 0.20 to 0.90). Conclusion Unprotected sex practices, number of sexual partners and lower educational levels may be useful for identifying women with L. iners-dominated microbiota and its suboptimal protective properties. L. iners microbiota does not seem to provide optimal protection against Candida sp. colonisation, warranting further investigation. | - |
Descrição: dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
Descrição: dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
Descrição: dc.description | Sao Paulo State Univ, Med Sch, Dept Pathol, UNESP, Botucatu, SP, Brazil | - |
Descrição: dc.description | Univ Maryland, Dept Microbiol & Immunol, Baltimore, MD 21201 USA | - |
Descrição: dc.description | Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA | - |
Descrição: dc.description | Sao Paulo State Univ, Med Sch, Dept Gynecol & Obstet, UNESP, Botucatu, SP, Brazil | - |
Descrição: dc.description | Univ Fed Parana, Dept Basic Pathol, Curitiba, Parana, Brazil | - |
Descrição: dc.description | Sao Paulo State Univ, Med Sch, Dept Pathol, UNESP, Botucatu, SP, Brazil | - |
Descrição: dc.description | Sao Paulo State Univ, Med Sch, Dept Gynecol & Obstet, UNESP, Botucatu, SP, Brazil | - |
Descrição: dc.description | FAPESP: 2012/16800-3 | - |
Descrição: dc.description | CAPES: 1680048 | - |
Formato: dc.format | 7 | - |
Idioma: dc.language | en | - |
Publicador: dc.publisher | Bmj Publishing Group | - |
Relação: dc.relation | Sexually Transmitted Infections | - |
???dc.source???: dc.source | Web of Science | - |
Palavras-chave: dc.subject | bacterial infections | - |
Palavras-chave: dc.subject | vaginosis | - |
Palavras-chave: dc.subject | bacterial | - |
Palavras-chave: dc.subject | molecular biology | - |
Palavras-chave: dc.subject | vaginal smears | - |
Palavras-chave: dc.subject | sexual behaviour | - |
Título: dc.title | Characteristics associated with Lactobacillus iners-dominated vaginal microbiota | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: