Adverse outcome pathways - development and potential regulatory application

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRossi Lima, Thania Rios [UNESP]-
Autor(es): dc.creatorSouza, Nathalia Pereira de [UNESP]-
Autor(es): dc.creatorPereira, Lilian Cristina [UNESP]-
Autor(es): dc.creatorViana de Camargo, Joao Lauro [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T21:58:47Z-
Data de disponibilização: dc.date.available2022-08-04T21:58:47Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.22239/2317-269x.01835-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/218653-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/218653-
Descrição: dc.descriptionIntroduction: Over the last two decades, chemical safety assessment and regulatory toxicology have progressed from empirical science based on direct observation of apical adverse outcomes in whole organisms to a predictive practice that infers outcomes and risks on the basis of accumulated understanding of toxicological mechanisms and modes of action. Objective: To provide general concepts on how Adverse Outcome Pathways (AOPs) are developed and examples related to skin sensitization, endocrine disruption, and mitochondrial dysfunction. Method: Narrative review based on data of the scientific literature relevant to the theme addressed and on the experience of the authors. Results: An AOP framework provides a systematic approach to organize knowledge about mechanisms of toxicity that may inform analytical domains in regulatory decision-making. AOPs are open structures that may indicate not only data gaps in the understanding of a toxicity process, but also testing procedures that will generate the necessary knowledge to fill those gaps. Every AOP should be continuously refined through the collaborative efforts of the scientific community. Depending on the amount and detail of information that is successively inserted, AOP may progress from the stage of a putative AOP to the stages of qualitative and quantitative AOPs, which are more fit-for-purpose to support regulatory decision-making. Conclusions: Continuous collaboration between AOP developers within the scientific community and the regulatory corps toward the development of this mechanistic structure will support the advancement of toxicological sciences, regardless of its immediate application for regulatory purposes.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCenter for Evaluation of Environmental Impact on Human Health (Nucleo de Avaliacao do Impacto Ambiental sobre a Saude Humana - TOXICAM)-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP), Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Ctr Evaluat Environm Impact Human Hlth TOXICAM, Dept Pathol, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Sch Agr Sci, Dept Bioproc & Biotechnol, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Ctr Evaluat Environm Impact Human Hlth TOXICAM, Dept Pathol, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Sch Agr Sci, Dept Bioproc & Biotechnol, Botucatu, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2017/25402-5-
Formato: dc.format2-13-
Idioma: dc.languageen-
Publicador: dc.publisherFundacao Oswaldo Cruz, Inst Nacional Controle Qualidade & Saude-
Relação: dc.relationVigilancia Sanitaria Em Debate-sociedade Ciencia & Tecnologia-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectAdverse Outcome Pathways-
Palavras-chave: dc.subjectHazard Assessment-
Palavras-chave: dc.subjectMode of Action-
Palavras-chave: dc.subjectRisk Assessment-
Palavras-chave: dc.subjectRegulatory Toxicology-
Título: dc.titleAdverse outcome pathways - development and potential regulatory application-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.