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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Federal de São Paulo (UNIFESP) | - |
Autor(es): dc.contributor | Inst Butantan | - |
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (UNESP) | - |
Autor(es): dc.creator | Medina-Pestana, Jose | - |
Autor(es): dc.creator | Covas, Dimas Tadeu | - |
Autor(es): dc.creator | Viana, Laila Almeida | - |
Autor(es): dc.creator | Dreige, Yasmim Cardoso | - |
Autor(es): dc.creator | Nakamura, Monica Rika | - |
Autor(es): dc.creator | Lucena, Elizabeth Franca | - |
Autor(es): dc.creator | Requiao-Moura, Lucio R. | - |
Autor(es): dc.creator | Branco Fortaleza, Carlos Magno Castelo [UNESP] | - |
Autor(es): dc.creator | Foresto, Renato Demarchi | - |
Autor(es): dc.creator | Tedesco-Silva, Helio | - |
Autor(es): dc.creator | Cristelli, Marina Pontello | - |
Data de aceite: dc.date.accessioned | 2022-08-04T21:58:35Z | - |
Data de disponibilização: dc.date.available | 2022-08-04T21:58:35Z | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2022-04-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1097/TP.0000000000004036 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/218590 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/218590 | - |
Descrição: dc.description | Background. Anti-severe acute respiratory syndrome coronavirus 2 mRNA vaccines elicit lower humoral responses in solid-organ transplant recipients. This is the first prospective trial investigating the effect of an inactivated whole-virion vaccine in kidney transplant recipients. Methods. Prospective, single-center, phase 4, interventional study. Kidney transplant recipients aged 30-69 y with >30 d of transplantation received two 3 mu g intramuscular doses of CoronaVac 28 d apart and are being followed for 6 mo. Primary outcomes: (1) reactogenicity after first dose; (2) antibody responses 28 d after each dose; and (3) incidence/severity of confirmed coronavirus disease 2019 (COVID-19) and 28-d lethality rate. For this analysis, clinical effectiveness was assessed for 3 mo, starting 15 d after the second dose, and compared with 3-mo period before vaccination. Results. Of the 3371 individuals who received the first dose, 99% completed vaccination schedule. Mild/local adverse reactions were reported by 33% of the patients. In the immunogenicity cohort (n = 942), the proportion of patients with IgG antibodies to severe acute respiratory syndrome coronavirus 2 increased from 15.2% after first dose to 43% after second dose. Increase in antibody values after second dose was associated with higher proportion of patients with detected neutralizing antibodies. A significant reduction in the incidence of COVID-19 was observed (6.4% versus 4.2%; P < 0.0001), although the 28-d lethality rate remained unchanged (25% versus 22%; P = 0.534). In 45 patients from the immunogenicity cohort who developed COVID-19, all the 6 deaths occurred among those without antibody response (n = 22; 49%). Conclusions. CoronaVac vaccine was associated with low reactogenicity, low immunogenicity but reduced incidence of COVID-19 among kidney transplant recipients. The lack of reduction in lethality rates is perhaps associated with the low percentage of patients developing humoral response after the second dose. | - |
Descrição: dc.description | Univ Fed Sao Paulo UNIFESP, Hosp Rim, Nephrol Div, Borges Lagoa 960, BR-04038002 Sao Paulo, SP, Brazil | - |
Descrição: dc.description | Inst Butantan, Sao Paulo, Brazil | - |
Descrição: dc.description | Univ Sao Paulo, Ctr Cell Based Therapy CTC, Reg Blood Ctr Ribeirao Preto, Sao Paulo, Brazil | - |
Descrição: dc.description | Univ Estadual Paulista, Infect Dis Div, UNESP, Botucatu, SP, Brazil | - |
Descrição: dc.description | Univ Estadual Paulista, Infect Dis Div, UNESP, Botucatu, SP, Brazil | - |
Formato: dc.format | 853-861 | - |
Idioma: dc.language | en | - |
Publicador: dc.publisher | Lippincott Williams & Wilkins | - |
Relação: dc.relation | Transplantation | - |
???dc.source???: dc.source | Web of Science | - |
Título: dc.title | Inactivated Whole-virus Vaccine Triggers Low Response Against SARS-CoV-2 Infection Among Renal Transplant Patients: Prospective Phase 4 Study Results | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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