Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Maringá (UEM)-
Autor(es): dc.contributorUniversidade Federal de Lavras (UFLA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGaddini, Lucas Valeiras-
Autor(es): dc.creatorKomatsu de Alencar, Carlos Rodrigo-
Autor(es): dc.creatorPereira Azevedo, Taina Lorraine-
Autor(es): dc.creatorLima, Gabriela Geraldo de-
Autor(es): dc.creatorTomacheuski, Rubia Mitalli [UNESP]-
Autor(es): dc.creatorFerrante, Marcos-
Autor(es): dc.creatorTaffarel, Marilda Onghero-
Data de aceite: dc.date.accessioned2022-08-04T21:58:22Z-
Data de disponibilização: dc.date.available2022-08-04T21:58:22Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/0103-8478cr20200828-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/218510-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/218510-
Descrição: dc.descriptionThis study aimed to elucidate the sedative effect and physiological changes associated with the intramuscular injection of detomidine combined with morphine in horses. Six healthy crossbred horses, aged 2 to 10 years, were included. A crossover experimental design was used to compare the effects of intramuscular injection of 30 mu g/kg of detomidine alone (IMD) and intramuscular administration of 30 mu g/kg of detomidine and 0.1 mg/kg of morphine (IMDM). The degree of sedation, height of head above ground, were assessed at the time points before and 5, 10, 20, 30, 40, 50, 60, 75, 90, 105, and 120 minutes after drug administration, and heart rate, respiratory rate, systolic blood pressure, rectum temperature and intestinal motility were assessed at the time points before and 10, 20, 30, 40, 50, 60, 75, 90, 105, and 120 minutes after drug administration. The physiological parameters were analyzed using the Kruskal-Wallis test with Dunn's post-hoc test and analysis of variance with t-test for independent samples and the sedation scores using the Friedman test and Mann Whitney U-test. P-values <0.05 indicated a statistically significant difference. IMDM promoted a higher sedative effect as compared to IMD, but the sedation occurred inconsistently. Additionally, a reduction in intestinal motility was observed with IMDM at 60, 75, 90, and 105 minutes after administration. AIDA? promoted more variable sedation and prolonged reduction in the intestinal motility in the horses as compared to IMD.-
Descrição: dc.descriptionUniv Estadual Maringa, Dept Med Vet, Campus Ciencias Agr, BR-87507190 Umuarama, PR, Brazil-
Descrição: dc.descriptionUniv Fed Lavras UFLA, Dept Med Vet, Lavras, MG, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Med Vet, UNESP, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Med Vet, UNESP, Botucatu, SP, Brazil-
Formato: dc.format7-
Idioma: dc.languageen-
Publicador: dc.publisherUniv Federal Santa Maria-
Relação: dc.relationCiencia Rural-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectdeep sedation-
Palavras-chave: dc.subjecthorses-
Palavras-chave: dc.subjecthypnotics and sedatives-
Palavras-chave: dc.subjectdetomidine-
Palavras-chave: dc.subjectmorphine-
Título: dc.titleSedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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