Ingestible Osmotic Pill for In Vivo Sampling of Gut Microbiomes

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Autor(es): dc.contributorTufts Univ-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBiomed Primate Res Ctr-
Autor(es): dc.contributorUniv Utrecht-
Autor(es): dc.creatorNejad, Hojatollah Rezaei-
Autor(es): dc.creatorOliveira, Bruno C. M. [UNESP]-
Autor(es): dc.creatorSadeqi, Aydin-
Autor(es): dc.creatorDehkharghani, Amin-
Autor(es): dc.creatorKondova, Ivanela-
Autor(es): dc.creatorLangermans, Jan A. M.-
Autor(es): dc.creatorGuasto, Jeffrey S.-
Autor(es): dc.creatorTzipori, Saul-
Autor(es): dc.creatorWidmer, Giovanni-
Autor(es): dc.creatorSonkusale, Sameer R.-
Data de aceite: dc.date.accessioned2022-08-04T21:57:47Z-
Data de disponibilização: dc.date.available2022-08-04T21:57:47Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2019-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/aisy.201900053-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/218310-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/218310-
Descrição: dc.descriptionTechnologies capable of noninvasively sampling different locations in the gut upstream of the colon enable new insights into the role of organ-specific microbiota in human health. Herein, an ingestible, biocompatible, battery-less, 3D-printed microengineered pill with an integrated osmotic sampler and microfluidic channels for in vivo sampling of the gut lumen and its microbiome upstream of the colon is discussed. The pill's sampling performance is characterized using realistic in vitro models and validated in vivo in pigs and primates. Herein, the results show that the bacterial populations recovered from the pill's microfluidic channels closely resemble the bacterial population demographics of the microenvironment to which the pill is exposed. Herein, it is believed that such lab-on-a-pill devices revolutionize the understanding of the spatial diversity of the gut microbiome and its response to medical conditions and treatments.-
Descrição: dc.descriptionOffice of Naval Research (ONR)-
Descrição: dc.descriptionNational Institute of Allergy and Infectious Diseases-
Descrição: dc.descriptionNational Science Foundation-
Descrição: dc.descriptionTufts Univ, Dept Elect & Comp Engn, 161 Coll Ave, Medford, MA 02155 USA-
Descrição: dc.descriptionTufts Univ, Nano Lab, Adv Technol Lab, 200 Boston Ave, Medford, MA 02155 USA-
Descrição: dc.descriptionTufts Univ, Cummings Sch Vet Med, North Grafton, MA 01536 USA-
Descrição: dc.descriptionTufts Univ, Dept Mech Engn, 200 Coll Ave, Medford, MA 02155 USA-
Descrição: dc.descriptionUniv Estadual Paulista UNESP, Fac Med Vet, BR-16050680 Aracatuba, Brazil-
Descrição: dc.descriptionBiomed Primate Res Ctr, Anim Sci Dept, Lange Kleiweg 161, NL-2288 GJ Rijswijk, Netherlands-
Descrição: dc.descriptionUniv Utrecht, Fac Vet Med, Dept Anim Sci & Soc, Yalelaan 2, NL-3584 CM Utrecht, Netherlands-
Descrição: dc.descriptionUniv Estadual Paulista UNESP, Fac Med Vet, BR-16050680 Aracatuba, Brazil-
Descrição: dc.descriptionOffice of Naval Research (ONR): N0014-16-1-2550-
Descrição: dc.descriptionNational Institute of Allergy and Infectious Diseases: 5R21AI125891-
Descrição: dc.descriptionNational Science Foundation: CBET-1511340-
Descrição: dc.descriptionNational Science Foundation: CAREER-1554095-
Formato: dc.format11-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-Blackwell-
Relação: dc.relationAdvanced Intelligent Systems-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectbiomedical devices-
Palavras-chave: dc.subjectlab-on-a-chip-
Palavras-chave: dc.subjectmicrobiomes-
Palavras-chave: dc.subjectmicrofluidics-
Palavras-chave: dc.subjectsmart pills-
Título: dc.titleIngestible Osmotic Pill for In Vivo Sampling of Gut Microbiomes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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