RADIOPROTECTION: MECHANISMS AND RADIOPROTECTIVE AGENTS INCLUDING HONEYBEE VENOM

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorVaranda, E. A. [UNESP]-
Autor(es): dc.creatorTavares, D. C. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T01:13:01Z-
Data de disponibilização: dc.date.available2022-02-22T01:13:01Z-
Data de envio: dc.date.issued2021-07-14-
Data de envio: dc.date.issued2021-07-14-
Data de envio: dc.date.issued1998-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S0104-79301998000100002-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/212331-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/212331-
Descrição: dc.descriptionSince 1949, a great deal of research has been carried out on the radioprotective action of chemical substances. These substances have shown to reduce mortality when administered to animals prior to exposure to a lethal dose of radiation. This fact is of considerable importance since it permits reduction of radiation-induced damage and provides prophylactic treatment for the damaging effects produced by radiotherapy. The following radioprotection mechanisms were proposed: free radical scavenger, repair by hydrogen donation to target molecules, formation of mixed disulfides, delay of cellular division and induction of hypoxia in the tissues. Radioprotective agents have been divided into four major groups: the thiol compounds, other sulfur compounds, pharmacological agents (anesthetic drugs, analgesics, tranquilizers, etc.) and other radioprotective agents (WR-1065, WR-2721, vitamins C and E, glutathione, etc.). Several studies revealed the radioprotective action of Apis mellifera honeybee venom as well as that of its components mellitin and histamine. Radioprotective activity of bee venom involves mainly the stimulation of the hematopoietic system. In addition, release of histamine and reduction in oxygen tension also contribute to the radioprotective action of bee venom.-
Descrição: dc.descriptionSão Paulo State University, Department of Biological Sciences, School of Pharmaceutical Sciences of Araraquara-
Descrição: dc.descriptionUNESP, São Paulo State University, Botucatu, SP, Brazil., Center for the Study of Venoms and Venomous Animals, CEVAP-
Descrição: dc.descriptionSão Paulo State University, Department of Biological Sciences, School of Pharmaceutical Sciences of Araraquara-
Descrição: dc.descriptionUNESP, São Paulo State University, Botucatu, SP, Brazil., Center for the Study of Venoms and Venomous Animals, CEVAP-
Formato: dc.format5-21-
Idioma: dc.languageen-
Publicador: dc.publisherCentro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP-
Relação: dc.relationJournal of Venomous Animals and Toxins-
Direitos: dc.rightsAcesso aberto-
???dc.source???: dc.sourceSciELO-
Palavras-chave: dc.subjectradiation-
Palavras-chave: dc.subjectprotective agents-
Palavras-chave: dc.subjecthoneybee venom-
Título: dc.titleRADIOPROTECTION: MECHANISMS AND RADIOPROTECTIVE AGENTS INCLUDING HONEYBEE VENOM-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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