EFFECT OF Crotalus durissus terrificus (LAURENTI, 1768) VENOM ON THE EVOLUTION OF EHRLICH ASCITES TUMOR

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorSchool of Medicine of Botucatu-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorSilva, R. J. Da [UNESP]-
Autor(es): dc.creatorFecchio, D.-
Autor(es): dc.creatorBarraviera, B. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T01:13:01Z-
Data de disponibilização: dc.date.available2022-02-22T01:13:01Z-
Data de envio: dc.date.issued2021-07-14-
Data de envio: dc.date.issued2021-07-14-
Data de envio: dc.date.issued1997-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S0104-79301997000200008-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/212329-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/212329-
Descrição: dc.descriptionThe effect of Crotalus durissus terrificus (LAURENTI, 1768) venom on the evolution of Ehrlich ascites tumor cells was evaluated. Thus, 30-day-old male mice of the Swiss strain were inoculated intraperitoneally with 1x10<img SRC=http:/img/fbpe/jvat/v3n2/image1947.gif> tumor cells. Then, 7 groups of animals were formed: 3 control groups (physiological, venom and tumor) and 4 experimental groups that received different doses of venom. The experimental groups received 5 intraperitoneal venom injections on the 1<img SRC=http:/img/fbpe/jvat/v3n2/image1948.gif> , 4<img SRC=http:/img/fbpe/jvat/v3n2/image1949.gif> , 7<img SRC=http:/img/fbpe/jvat/v3n2/image1949.gif> , 10<img SRC=http:/img/fbpe/jvat/v3n2/image1949.gif> and 13<img SRC=http:/img/fbpe/jvat/v3n2/image1949.gif> days after tumor implantation. On the 14<img SRC=http:/img/fbpe/jvat/v3n2/image1949.gif width=28 height=28> day, 5 animals from each one of the groups were sacrificed, and the variables such as the total and differential counts of cells in the peritoneal cavity and functional state of peritoneal macrophages by macrophage spreading were evaluated. The other 5 remaining animals were kept in the laboratory for 60 days for observation of their survival percentage. The results obtained were statistically analyzed by the Kruskal-Wallis test at 5% significance level. It was observed that Crotalus durissus terrificus venom increases survival time of mice, but does not increase mortality percentage. This venom also increases the percentage of macrophage spreading. We suggest that snake venoms can cause inhibition of tumor growth by activating the inflammatory reaction, mainly the macrophages, stimulating the production of TNF-<img SRC=http:/img/fbpe/jvat/v3n2/image1950.gif> , IL-1, IL-6 and IL-8. These cytokines may act on tumor cells by different mechanisms, inducing its complete elimination.-
Descrição: dc.descriptionSchool of Medicine of Botucatu, Department of Tropical Diseases-
Descrição: dc.descriptionUNESP, Center for the Study of Venoms and Venomous Animals - CEVAP-
Descrição: dc.descriptionSchool of Medicine of Botucatu, Department of Pathology-
Descrição: dc.descriptionUNESP, Center for the Study of Venoms and Venomous Animals - CEVAP-
Formato: dc.format324-341-
Idioma: dc.languageen-
Publicador: dc.publisherCentro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP-
Relação: dc.relationJournal of Venomous Animals and Toxins-
Direitos: dc.rightsAcesso aberto-
???dc.source???: dc.sourceSciELO-
Palavras-chave: dc.subjectvenom-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjecttumor growth-
Palavras-chave: dc.subjectCrotalus durissus terrificus-
Título: dc.titleEFFECT OF Crotalus durissus terrificus (LAURENTI, 1768) VENOM ON THE EVOLUTION OF EHRLICH ASCITES TUMOR-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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