Chitosan-based systems aimed at local application for vaginal infections

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorSousa Araujo, Victor Hugo [UNESP]-
Autor(es): dc.creatorChaves de Souza, Mauricio Palmeira [UNESP]-
Autor(es): dc.creatorCarvalho, Gabriela Correa [UNESP]-
Autor(es): dc.creatorDuarte, Jonatas Lobato [UNESP]-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T01:06:34Z-
Data de disponibilização: dc.date.available2022-02-22T01:06:34Z-
Data de envio: dc.date.issued2021-06-26-
Data de envio: dc.date.issued2021-06-26-
Data de envio: dc.date.issued2021-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.carbpol.2021.117919-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210735-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210735-
Descrição: dc.descriptionVaginal administration is a promising route for the local treatment of infectious vaginal diseases since it can bypass the first-pass metabolism, drug interactions, and adverse effects. However, the commercial products currently available for topical vulvovaginal treatment have low acceptability and do not adequately explore this route. Mucoadhesive systems can optimize the efficacy of drugs administered by this route to increase the retention time of the drug in the vaginal environment. Several polymers are used to develop mucoadhesive systems, among them chitosan, a natural polymer that is highly biocompatible and technologically versatile. Thus, the present review aimed to analyze the studies that used chitosan to develop mucoadhesive systems for the treatment of local vaginal infections. These studies demonstrated that chitosan as a component of mucoadhesive drug delivery systems (DDS) is a promising device for the treatment of vaginal infectious diseases, due to the intrinsic antimicrobial activity of this biopolymer and because it does not interfere with the effectiveness of the drugs used for the treatment.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSao Paulo State Univ, Sch Pharmaceut Sci, Araraquara, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Sch Pharmaceut Sci, Araraquara, SP, Brazil-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2019/10261-2-
Descrição: dc.descriptionFAPESP: 2019/25125-7-
Formato: dc.format11-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationCarbohydrate Polymers-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectChitosan-
Palavras-chave: dc.subjectBacterial vaginosis-
Palavras-chave: dc.subjectVulvovaginal candidiasis-
Palavras-chave: dc.subjectTrichomoniasis-
Palavras-chave: dc.subjectVaginitis-
Título: dc.titleChitosan-based systems aimed at local application for vaginal infections-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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