Preventive activity of Copaifera langsdorffii Desf. leaves extract and its major compounds, afzelin and quercitrin, on DNA damage in in vitro and in vivo models

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniv Franca-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorOzelin, Saulo Duarte-
Autor(es): dc.creatorSenedese, Juliana Marques-
Autor(es): dc.creatorAlves, Jacqueline Morais-
Autor(es): dc.creatorMunari, Carla Carolina-
Autor(es): dc.creatorCosta, Juliana De Carvalho Da-
Autor(es): dc.creatorResende, Flavia Aparecida [UNESP]-
Autor(es): dc.creatorCampos, Debora Leite [UNESP]-
Autor(es): dc.creatorLima, Ildercilio Mota De Souza-
Autor(es): dc.creatorAndrade, Augusto Faria-
Autor(es): dc.creatorVaranda, Eliana Aparecida [UNESP]-
Autor(es): dc.creatorBastos, Jairo Kenupp-
Autor(es): dc.creatorTavares, Denise Crispim-
Data de aceite: dc.date.accessioned2022-02-22T01:06:31Z-
Data de disponibilização: dc.date.available2022-02-22T01:06:31Z-
Data de envio: dc.date.issued2021-06-26-
Data de envio: dc.date.issued2021-06-26-
Data de envio: dc.date.issued2021-03-17-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/15287394.2021.1898505-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210727-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210727-
Descrição: dc.descriptionCopaifera langsdorffii Desf. is a plant found in South America, especially in Brazil. Oleoresin and the leaves of this plant is used as a popular medicinal agent. However, few studies on the chemical composition of aerial parts and related biological activities are known. This study aimed to examine the cytotoxic, genotoxic, and antigenotoxic potential of C. langsdorffii aerial parts hydroalcoholic extract (CLE) and two of its major compounds afzelin and quercitrin. The cytotoxic and antigenotoxic potential of CLE was determined as follows: 1) against genotoxicity induced by doxorubicin (DXR) or methyl methanesulfonate (MMS) in V79 cells; 2) by direct and indirect-acting mutagens in Salmonella typhimurium strains; and 3) by MMS in male Swiss mice. The protective effects of afzelin and quercitrin against DXR or MMS were also evaluated in V79 and HepG2 cells. CLE was cytotoxic as evidenced by clonogenic efficiency assay. Further, CLE did not induce a significant change in frequencies of chromosomal aberrations and micronuclei; as well as number of revertants in the Ames test demonstrating absence of genotoxicity. In contrast, CLE was found to be antigenotoxic in mammalian cells. The results also showed that CLE exerted inhibitory effect against indirect-acting mutagens in the Ames test. Afzelin and quercitrin did not reduce genotoxicity induced by DXR or MMS in V79 cells. However, treatments using afzelin and quercitrin decreased MMS-induced genotoxicity in HepG2 cells. The antigenotoxic effect of CLE observed in this study may be partially attributed to the antioxidant activity of the combination of major components afzelin and quercitrin.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniv Franca, Lab Mutagenese, Franca, SP, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Fac Ciencias Farmaceut Araraquara, Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Fac Ciencias Farmaceut Araraquara, Araraquara, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2011/1360-7-
Formato: dc.format569-581-
Idioma: dc.languageen-
Publicador: dc.publisherTaylor & Francis Inc-
Relação: dc.relationJournal Of Toxicology And Environmental Health-part A-current Issues-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectCopaifera langsdorffii-
Palavras-chave: dc.subjectafzelin-
Palavras-chave: dc.subjectquercitrin-
Palavras-chave: dc.subjectgenotoxicity-
Palavras-chave: dc.subjectantigenotoxicity-
Título: dc.titlePreventive activity of Copaifera langsdorffii Desf. leaves extract and its major compounds, afzelin and quercitrin, on DNA damage in in vitro and in vivo models-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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