Association between hydrochlorothiazide and the risk of in situ and invasive squamous cell skin carcinoma and basal cell carcinoma: A population-based case-control study

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorSanta Casa Misericordia Rio de Janeiro-
Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.contributorUniversidade do Estado do Rio de Janeiro (UERJ)-
Autor(es): dc.contributorUniv Fed Parana-
Autor(es): dc.contributorSanta Casa Misericordia-
Autor(es): dc.contributorUniversidade de Brasília (UnB)-
Autor(es): dc.contributorSanta Casa Sao Paulo-
Autor(es): dc.creatorRamos, Paulo Muller [UNESP]-
Autor(es): dc.creatorAnzai, Alessandra-
Autor(es): dc.creatorDuque-Estrada, Bruna-
Autor(es): dc.creatorFarias, Debora Cadore-
Autor(es): dc.creatorMelo, Daniel Fernandes-
Autor(es): dc.creatorMulinari-Brenner, Fabiane-
Autor(es): dc.creatorPinto, Giselle Martins-
Autor(es): dc.creatorAbraham, Leonardo Spagnol-
Autor(es): dc.creatorNogueira Santos, Leopoldo Duailibe-
Autor(es): dc.creatorPirmez, Rodrigo-
Autor(es): dc.creatorMiot, Helio Amante [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T01:05:43Z-
Data de disponibilização: dc.date.available2022-02-22T01:05:43Z-
Data de envio: dc.date.issued2021-06-26-
Data de envio: dc.date.issued2021-06-26-
Data de envio: dc.date.issued2021-03-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210696-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210696-
Descrição: dc.descriptionBackground: Population-based studies analyzing hydrochlorothiazide's (HCTZ's) effect on keratinocyte carcinoma, and particularly invasive squamous cell carcinoma (SCC), are lacking. Objectives: To characterize the association between HCTZ use and invasive SCC, SCC in situ (SCCis), and basal cell carcinoma (BCC). Methods: This population-based case-control study included all 6880 patients diagnosed with first-time BCC, SCCis, and invasive SCC between 2003 and 2017 in Iceland and 69,620 population controls. Conditional logistic regression analyses were used to calculate multivariate odds ratios (ORs) for keratinocyte carcinoma associated with HCTZ use. Results: A cumulative HCTZ dose above 37,500 mg was associated with increased risk of invasive SCC (OR, 1.69; 95% confidence interval [CI], 1.04-2.74). Users of HCTZ also had an increased risk of SCCis (OR, 1.24; 95% CI, 1.01-1.52) and BCC (OR, 1.14; 95% CI, 1.02-1.29). Limitations: Limitations include this study's retrospective nature with the resulting inability to adjust for ultraviolet exposure, Fitzpatrick skin type, and comorbidities. Conclusions: High cumulative exposure to HCTZ is associated with the development of keratinocyte carcinoma and, most importantly, invasive SCC. Sun protective behaviors alone may not eliminate the carcinogenic potential of HCTZ.-
Descrição: dc.descriptionUniv Estadual Paulista, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Sao Paulo, Brazil-
Descrição: dc.descriptionSanta Casa Misericordia Rio de Janeiro, Rio De Janeiro, Brazil-
Descrição: dc.descriptionUniv Fed Santa Catarina, Florianopolis, SC, Brazil-
Descrição: dc.descriptionUniv Estado Rio De Janeiro, Rio De Janeiro, Brazil-
Descrição: dc.descriptionUniv Fed Parana, Curitiba, Parana, Brazil-
Descrição: dc.descriptionSanta Casa Misericordia, Porto Alegre, RS, Brazil-
Descrição: dc.descriptionUniv Brasilia, Brasilia, DF, Brazil-
Descrição: dc.descriptionSanta Casa Sao Paulo, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Botucatu, SP, Brazil-
Formato: dc.format712-718-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationJournal Of The American Academy Of Dermatology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectbasal cell carcinoma-
Palavras-chave: dc.subjectepidemiology-
Palavras-chave: dc.subjecthydrochlorothiazide-
Palavras-chave: dc.subjectkeratinocyte carcinoma-
Palavras-chave: dc.subjectsquamous cell carcinoma-
Título: dc.titleAssociation between hydrochlorothiazide and the risk of in situ and invasive squamous cell skin carcinoma and basal cell carcinoma: A population-based case-control study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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