Aqueous extract of Paullinia cupana attenuates renal and hematological effects associated with ketoprofen

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Ponta Grossa (UEPG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.contributorUniversidade Federal de Sergipe (UFS)-
Autor(es): dc.creatorBello, Caroline-
Autor(es): dc.creatorPrestes, Ana Paula-
Autor(es): dc.creatorSchemberger, Josiane Aparecida-
Autor(es): dc.creatorHacke, Ana Carolina Mendes-
Autor(es): dc.creatorPereira, Romaiana Picada-
Autor(es): dc.creatorManente, Francine Alessandra [UNESP]-
Autor(es): dc.creatorCarlos, Iracilda Zeppone [UNESP]-
Autor(es): dc.creatorAndrade, Cleverton Roberto de [UNESP]-
Autor(es): dc.creatorFernandes, Daniel-
Autor(es): dc.creatorCruz, Ivana Beatrice Manica da-
Autor(es): dc.creatorUnfer, Tais Cristina-
Autor(es): dc.creatorVellosa, Jose Carlos Rebuglio-
Data de aceite: dc.date.accessioned2022-02-22T01:03:08Z-
Data de disponibilização: dc.date.available2022-02-22T01:03:08Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-02-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jfbc.13560-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210576-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210576-
Descrição: dc.descriptionThis study aimed to evaluate the effect of aqueous extract of Paullinia cupana (AEG) against ketoprofen side effects, through biochemical, hematological, and histological parameters. AEG showed antioxidant activity in the DPPH center dot scavenging (IC50 = 17.00 +/- 1.00 mu g/ml) and HPLC analysis revealed that this extract is constituted by antioxidants (caffeine, catechins, theobromine, and polyphenols). In vivo experiments in female Wistar rats demonstrated that alterations in urea, creatinine, and uric acid levels promoted (p < .05) by ketoprofen were reversed when AEG was co-administered. Ketoprofen significantly decreased the catalase levels of animal tissues (p < .05), which were restored when AEG was co-administered with the mentioned drug. Histological analysis showed that AEG protected tissues from damages caused by ketoprofen. Moreover, AEG reestablished the number of white blood cells, which had decreased when ketoprofen was administered. In conclusion, this study suggested that the association between ketoprofen and AEG may be an alternative to reduce health damages caused by this drug. Practical applications Paullinia cupana, popularly known as guarana, is commonly consumed as a beverage in Brazil and exhibits pharmacological and beneficial effects to humans. Ketoprofen is an efficacious drug employed in the treatment of inflammatory processes. However, this drug can cause several side effects in humans. Thus, the usage of natural products and plant extracts that can reduce such undesirable effects consists in a valuable strategy to be applied in therapeutic interventions.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionUniv Estadual Ponta Grossa, Dept Anal Clin & Toxicol, Ponta Grossa, Parana, Brazil-
Descrição: dc.descriptionUniv Estadual Ponta Grossa, Dept Quim, Ponta Grossa, Parana, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Anal Clin, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Fisiol & Patol, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Fed Santa Catarina, Dept Farmacol, Florianopolis, SC, Brazil-
Descrição: dc.descriptionUniv Fed Santa Maria, Lab Biogen, Santa Maria, RS, Brazil-
Descrição: dc.descriptionUniv Fed Sergipe, Dept Farm, Sao Cristovao, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Anal Clin, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Fisiol & Patol, Sao Paulo, Brazil-
Formato: dc.format12-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-Blackwell-
Relação: dc.relationJournal Of Food Biochemistry-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectantioxidant-
Palavras-chave: dc.subjectcatalase-
Palavras-chave: dc.subjectDPPH-
Palavras-chave: dc.subjectguarana-
Palavras-chave: dc.subjectketoprofen-
Palavras-chave: dc.subjectkidney damage-
Título: dc.titleAqueous extract of Paullinia cupana attenuates renal and hematological effects associated with ketoprofen-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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