Polymorphism in the IL-1 beta promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorLisboa Univ-
Autor(es): dc.contributorUniversidade Federal de Sergipe (UFS)-
Autor(es): dc.contributorHlth Minist-
Autor(es): dc.contributorUniv Fed Para-
Autor(es): dc.contributorUniversidade Federal Fluminense (UFF)-
Autor(es): dc.contributorFiocruz MS-
Autor(es): dc.creatorCapobianco, Marcela Petrolini [UNESP]-
Autor(es): dc.creatorCassiano, Gustavo Capatti-
Autor(es): dc.creatorStorti-Melo, Luciane Moreno-
Autor(es): dc.creatorPimenta, Tamirys Simao-
Autor(es): dc.creatorDrummond Rodrigues, Ana Paula-
Autor(es): dc.creatorGomes Arruda, Jose Eduardo-
Autor(es): dc.creatorPinto, Marcia Ribeiro-
Autor(es): dc.creatorSouza Baptista, Andrea Regina de-
Autor(es): dc.creatorPratt-Riccio, Lilian Rose-
Autor(es): dc.creatorBonini-Domingos, Claudia Regina [UNESP]-
Autor(es): dc.creatorDe Oliveira-Ferreira, Joseli-
Autor(es): dc.creatorDantas Machado, Ricardo Luiz [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T01:02:38Z-
Data de disponibilização: dc.date.available2022-02-22T01:02:38Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/trstmh/traa055-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210560-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210560-
Descrição: dc.descriptionBackground: It is well established that infection by Plasmodium vivax is a result of host-parasite interactions. In the present study, association with the IL1/IL2 cytokine profiles, anticircumsporozoite protein antibody levels and parasitic loads was evaluated in individuals naturally infected with P. vivax in an endemic area of the Brazilian Amazon. Methods: Molecular diagnosis of P. vivax and variants was performed using the PCR-RFLP method and IL1B -511C>T, IL2 -330T>G and IL2+114T>G polymorphisms were identified using PCR-RFLP and allele-specific PCR. IL-1 beta and IL-2 cytokine levels were detected by flow cytometry and circumsporozoite protein (CSP) antibodies were measured by ELISA. Results: Three variants of P. vivax CSP were identified and VK247 was found to be the most frequent. However, the prevalence and magnitude of IgG antibodies were higher for the VK210 variant. Furthermore, the antibody response to the CSP variants was not associated with the presence of the variant in the infection. Significant differences were observed between the single nucleotide polymorphism (SNP) -511T>C in the IL1B gene and levels of antibodies to the VK247 and P. vivax-like variants, but there were no associations between SNPs in IL1 and IL2 genes and their plasma products. Conclusions: Individuals with the rs16944 CC genotype in the IL1 beta gene have higher antibody levels to the CSP of P. vivax of VK247 and P. vivax-like variants.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSao Paulo State Univ, Grad Program Biosci, Sao Jose Do Rio Preto, SP, Brazil-
Descrição: dc.descriptionLisboa Univ, Trop Med & Hyg Inst, Global Hlth & Trop Med, Lisbon, Portugal-
Descrição: dc.descriptionUniv Fed Sergipe, Dept Biol, Aracaju, Sergipe, Brazil-
Descrição: dc.descriptionHlth Minist, Lab Malaria Immunogenet, Evandro Chagas Inst, Belem, Para, Brazil-
Descrição: dc.descriptionUniv Fed Para, Evandro Chagas Inst, Electron Microscopy Lab, Hlth Minist, Belem, Para, Brazil-
Descrição: dc.descriptionFluminense Fed Univ, Ctr Microorganisms Invest, Niteroi, RJ, Brazil-
Descrição: dc.descriptionFiocruz MS, Oswaldo Cruz Inst, Lab Malaria Res, Rio De Janeiro, Brazil-
Descrição: dc.descriptionFiocruz MS, Lab Immunoparasitol, Oswaldo Cruz Inst, Rio De Janeiro, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Grad Program Biosci, Sao Jose Do Rio Preto, SP, Brazil-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format858-865-
Idioma: dc.languageen-
Publicador: dc.publisherOxford Univ Press-
Relação: dc.relationTransactions Of The Royal Society Of Tropical Medicine And Hygiene-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectantibodies-
Palavras-chave: dc.subjectcircumsporozoite protein-
Palavras-chave: dc.subjectIL-1-
Palavras-chave: dc.subjectIL-2-
Palavras-chave: dc.subjectPlasmodium vivax-
Palavras-chave: dc.subjectpolymorphisms-
Título: dc.titlePolymorphism in the IL-1 beta promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.