Is the efflux pump inhibitor Verapamil a potential booster for isoniazid against Mycobacterium tuberculosis?

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Autor(es): dc.contributorUniversidade Estadual de Maringá (UEM)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorRibeiro do Amaral, Renata Claro-
Autor(es): dc.creatorCaleffi-Ferracioli, Katiany Rizzieri-
Autor(es): dc.creatorDemitto, Fernanda de Oliveira-
Autor(es): dc.creatorAlmeida, Aryadne Larissa de-
Autor(es): dc.creatorDias Siqueira, Vera Lucia-
Autor(es): dc.creatorLima Scodro, Regiane Bertin de-
Autor(es): dc.creatorFujimura Leite, Clarice Queico [UNESP]-
Autor(es): dc.creatorPavan, Fernando Rogerio [UNESP]-
Autor(es): dc.creatorCardoso, Rosilene Fressatti-
Data de aceite: dc.date.accessioned2022-02-22T01:02:37Z-
Data de disponibilização: dc.date.available2022-02-22T01:02:37Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/s2175-97902020000218309-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210553-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210553-
Descrição: dc.descriptionThe membrane-based efflux pump systems are recognized to have an important role in pathogenicity and drug resistance in Mycobacterium tuberculosis by the extrusion of toxic substrates and drugs from the inner bacillus. This study aimed to investigate the in vitro interaction of Verapamil (VP), an efflux pump inhibitor, with the classical first-line anti-tuberculosis drug isoniazid (INH) in resistant and susceptible M. tuberculosis clinical isolates. Seven multidrug-resistant (MDR), three INH monoresistant and four susceptible M. tuberculosis clinical isolates were tested for the INH and VP combination by modified Resazurin Microtiter Assay Plate (REMA). Fractional Inhibitory Concentration (FIC) and Modulation Factor (MF) were determined. The INH plus VP combination showed no significant change in the Minimum inhibitory concentration (M IC) values of INH (FIC >= 0.5; MF=1 or 2).The use of VP in tuberculosis therapy should be managed carefully, considering the resistance caused by specific mutation in katG and inhA genes, in which the use of these EPIs may have no success. The use of EPIs as an adjunctive drug in the anti-tuberculosis therapy should be further investigated on a larger number of M. tuberculosis clinical isolates with different resistant profile.-
Descrição: dc.descriptionUniv Estadual Maringa, Biosci & Physiopathol, Maringa, Parana, Brazil-
Descrição: dc.descriptionUniv Estadual Maringa, Hlth Sci, Maringa, Parana, Brazil-
Descrição: dc.descriptionUniv Estadual Maringa, Dept Clin Anal & Biomed, Lab Med Bacteriol, Maringa, Parana, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Sch Pharmaceut Sci, Lab Mycobacteriol Prof Dr Hugo David, Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Sch Pharmaceut Sci, Lab Mycobacteriol Prof Dr Hugo David, Araraquara, SP, Brazil-
Formato: dc.format7-
Idioma: dc.languageen-
Publicador: dc.publisherUniv Sao Paulo, Conjunto Quimicas-
Relação: dc.relationBrazilian Journal Of Pharmaceutical Sciences-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectTuberculosis-
Palavras-chave: dc.subjectMultidrug-resistance-
Palavras-chave: dc.subjectEfflux pumps-
Palavras-chave: dc.subjectEfflux pumps inhibitors-
Palavras-chave: dc.subjectisoniazid-
Título: dc.titleIs the efflux pump inhibitor Verapamil a potential booster for isoniazid against Mycobacterium tuberculosis?-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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