Erythroxylum pungens Tropane Alkaloids: GC-MS Analysis and the Bioactive Potential of 3-(2-methylbutyryloxy)tropan-6,7-diol in Zebrafish ( Danio rerio )

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Autor(es): dc.contributorUniv Fed Rio Grande do Norte-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorUniv Fed Rio Grande do Sul-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorLambert Moreira, Leticia Gondim-
Autor(es): dc.creatorLeite Ferreira, Maria Elisa-
Autor(es): dc.creatorSantos Reginaldo, Fernanda Priscila-
Autor(es): dc.creatorGuimaraes Lourenco, Estela Mariana-
Autor(es): dc.creatorSilveira Zuanazzi, Jose Angelo-
Autor(es): dc.creatorBarbosa, Euzebio Guimaraes-
Autor(es): dc.creatorFerreira, Leandro de Santis-
Autor(es): dc.creatorFett-Neto, Arthur Germano-
Autor(es): dc.creatorCavalheiro, Alberto Jose [UNESP]-
Autor(es): dc.creatorLuchiari, Ana Carolina-
Autor(es): dc.creatorGiordani, Raquel Brandt-
Data de aceite: dc.date.accessioned2022-02-22T01:02:03Z-
Data de disponibilização: dc.date.available2022-02-22T01:02:03Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-10-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1055/a-1264-4302-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210537-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210537-
Descrição: dc.descriptionTropane alkaloids are specialized plant metabolites mostly found in the Erythroxylaceae and Solanaceae families. Although tropane alkaloids have a high degree of structural similarity because of the tropane ring, their pharmacological actions are quite distinct. Brazil is one of the main hotspots of Erythroxylum spp. diversity with 123 species (almost 66% of the species catalogued in tropical America). Erythroxylum pungens occurs in the Caatinga, a promising biome that provides bioactive compounds, including tropane alkaloids. As part of our efforts to investigate this species, 15 alkaloids in specimens harvested under different environmental conditions are presented herein. The occurrence of 3-(2-methylbutyryloxy)tropan-6,7-diol in the stem bark of plants growing in their natural habitat, greenhouse controlled conditions, and after a period of water restriction, suggests that it is a potential chemical marker for the species. This alkaloid was evaluated for several parameters in zebrafish ( Danio rerio ) as a model organism. Regarding toxicity, teratogenic effects were observed at 19.5 mu M and the lethal dose for embryos was 18.4 mu M. No mortality was observed in adults, but a behavioral screen showed psychostimulatory action at 116.7 mu M. Overall, the alkaloid was able to cause zebrafish behavioral changes, prompting further investigation of its potential as a new molecule in the treatment of depression-like symptoms. In silico , targets involved in antidepressant pathways were identified by docking.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionINCT BioNat-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniv Fed Rio Grande do Norte, Dept Pharm, Gal Gustavo Cordeiro Farias St S-N, BR-59012570 Natal, RN, Brazil-
Descrição: dc.descriptionUniv Fed Rio Grande do Norte, Dept Physiol & Behav, Natal, RN, Brazil-
Descrição: dc.descriptionUniv Fed Mato Grosso do Sul, Fac Pharmaceut Sci Food & Nutr, Campo Grande, MS, Brazil-
Descrição: dc.descriptionUniv Fed Rio Grande do Sul, Fac Pharm, Porto Alegre, RS, Brazil-
Descrição: dc.descriptionUniv Fed Rio Grande do Sul, Ctr Biotechnol & Dept Bot, Porto Alegre, RS, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Chem Inst, Araraquara, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Chem Inst, Araraquara, SP, Brazil-
Descrição: dc.descriptionCNPq: 445149/2014-0-
Descrição: dc.descriptionINCT BioNat: 465637/2014-0-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2014/50926-0-
Formato: dc.format177-186-
Idioma: dc.languageen-
Publicador: dc.publisherGeorg Thieme Verlag Kg-
Relação: dc.relationPlanta Medica-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectErythroxylum pungens-
Palavras-chave: dc.subjectErythroxylaceae-
Palavras-chave: dc.subjecttropane alkaloids-
Palavras-chave: dc.subjectDanio rerio-
Palavras-chave: dc.subjectCyprinidae-
Palavras-chave: dc.subjectCaatinga-
Título: dc.titleErythroxylum pungens Tropane Alkaloids: GC-MS Analysis and the Bioactive Potential of 3-(2-methylbutyryloxy)tropan-6,7-diol in Zebrafish ( Danio rerio )-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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