Exploiting solid lipid nanoparticles and nanostructured lipid carriers for drug delivery against cutaneous fungal infections

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de Brasília (UnB)-
Autor(es): dc.creatorAraujo, Victor Hugo Sousa [UNESP]-
Autor(es): dc.creatorDelello Di Filippo, Leonardo [UNESP]-
Autor(es): dc.creatorDuarte, Jonatas Lobado [UNESP]-
Autor(es): dc.creatorSposito, Larissa [UNESP]-
Autor(es): dc.creatorFurquim de Camargo, Bruna Almeida [UNESP]-
Autor(es): dc.creatorSilva, Patricia Bento da-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T01:01:55Z-
Data de disponibilização: dc.date.available2022-02-22T01:01:55Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-02-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/1040841X.2020.1843399-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210532-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210532-
Descrição: dc.descriptionSeveral types of cutaneous fungal infections can affect the population worldwide, such as dermatophytosis, cutaneous candidiasis, onychomycosis, and sporotrichosis. However, oral treatments have pronounced adverse effects, making the topical route an alternative to avoid this disadvantage. On the other hand, currently available pharmaceutical forms designed for topical application, such as gels and creams, do not demonstrate effective retention of biomolecules in the upper layers of the skin. An interesting approach to optimise biomolecules' activity in the skin is the use of nanosystems for drug delivery, especially solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), which in the past decade has shown advantages like increased adhesiveness, great occlusive properties and higher biomolecule deposition in stratum corneum when designed for topical application. Considering the demand for more effective therapeutic alternatives and the promising characteristics of SLN and NLC for topical application, the present study sought to gather studies that investigated the potential of using SLN and NLC for the treatment of cutaneous fungal infections. Studies demonstrated that these nanosystems showed optimisation, mostly, of the effectiveness of biomolecules besides other biopharmaceutical properties, in addition to offering potential occlusion and hydration of the applied region.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSao Paulo State Univ, Sch Pharmaceut Sci, Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Brasilia, Inst Biol Sci, Dept Genet & Morphol, Lab Nanobiotechnol, Brasilia, DF, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Sch Pharmaceut Sci, Araraquara, SP, Brazil-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 18488-3-
Formato: dc.format79-90-
Idioma: dc.languageen-
Publicador: dc.publisherTaylor & Francis Ltd-
Relação: dc.relationCritical Reviews In Microbiology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectSolid lipid nanoparticles-
Palavras-chave: dc.subjectnanostructured lipid carriers-
Palavras-chave: dc.subjectdermatophytosis-
Palavras-chave: dc.subjectcutaneous candidiasis-
Palavras-chave: dc.subjectonychomycosis-
Palavras-chave: dc.subjectsporotrichosis-
Título: dc.titleExploiting solid lipid nanoparticles and nanostructured lipid carriers for drug delivery against cutaneous fungal infections-
Aparece nas coleções:Repositório Institucional - Unesp

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