The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2-infected patients by sex and age

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniv Freiburg-
Autor(es): dc.contributorHaraldsplass Deaconess Hosp-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniv Toronto-
Autor(es): dc.contributorUniv Washington-
Autor(es): dc.contributorSeattle Childrens Res Inst-
Autor(es): dc.contributorUniversal Sci Educ & Res Network-
Autor(es): dc.creatorFreire, Paula P.-
Autor(es): dc.creatorMarques, Alexandre H. C.-
Autor(es): dc.creatorBaiocchi, Gabriela C.-
Autor(es): dc.creatorSchimke, Lena F.-
Autor(es): dc.creatorFonseca, Dennyson L. M.-
Autor(es): dc.creatorSalgado, Ranieri C.-
Autor(es): dc.creatorFilgueiras, Igor S.-
Autor(es): dc.creatorNapoleao, Sarah M. S.-
Autor(es): dc.creatorPlaca, Desiree R.-
Autor(es): dc.creatorAkashi, Karen T.-
Autor(es): dc.creatorCrespo Hirata, Thiago Dominguez-
Autor(es): dc.creatorEl Khawanky, Nadia-
Autor(es): dc.creatorGiil, Lasse M.-
Autor(es): dc.creatorCabral-Miranda, Gustavo-
Autor(es): dc.creatorCarvalho, Robson F. [UNESP]-
Autor(es): dc.creatorFerreira, Luis Carlos S.-
Autor(es): dc.creatorCondino-Neto, Antonio-
Autor(es): dc.creatorNakaya, Helder-
Autor(es): dc.creatorJurisica, Igor-
Autor(es): dc.creatorOchs, Hans D.-
Autor(es): dc.creatorSaraiva Camara, Niels Olsen-
Autor(es): dc.creatorCalich, Vera Lucia G.-
Autor(es): dc.creatorCabral-Marques, Otavio-
Data de aceite: dc.date.accessioned2022-02-22T00:59:54Z-
Data de disponibilização: dc.date.available2022-02-22T00:59:54Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-24-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1172/jci.insight.147535-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210433-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210433-
Descrição: dc.descriptionThe fact that the COVID-19 fatality rate varies by sex and age is poorly understood. Notably, the outcome of SARS-CoV-2 infections mostly depends on the control of cytokine storm and the increasingly recognized pathological role of uncontrolled neutrophil activation. Here, we used an integrative approach with publicly available RNA-Seq data sets of nasopharyngeal swabs and peripheral blood leukocytes from patients with SARS-CoV-2, according to sex and age. Female and young patients infected by SARS-CoV-2 exhibited a larger number of differentially expressed genes (DEGs) compared with male and elderly patients, indicating a stronger immune modulation. Among them, we found an association between upregulated cytokine/chemokine- and downregulated neutrophil-related DEGs. This was correlated with a closer relationship between female and young subjects, while the relationship between male and elderly patients was closer still. The association between these cytokine/chemokines and neutrophil DEGs is marked by a strongly correlated interferome network. Here, female patients exhibited reduced transcriptional levels of key proinflammatory/neutrophil-related genes, such as CXCL8 receptors (CXCR1 and CXCR2), IL-1 beta, S100A9, ITGAM, and DBNL, compared with male patients. These genes are well known to be protective against inflammatory damage. Therefore, our work suggests specific immune-regulatory pathways associated with sex and age of patients infected with SARS-CoV-2 and provides a possible association between inverse modulation of cytokine/chemokine and neutrophil transcriptional signatures.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionOntario Research Fund-
Descrição: dc.descriptionNatural Sciences Research Council-
Descrição: dc.descriptionCanada Foundation for Innovation-
Descrição: dc.descriptionIBM-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSantander Universidades (Banco Santander Brasil S/A)-
Descrição: dc.descriptionUniv Sao Paulo, Dept Immunol, Inst Biomed Sci, Lineu Prestes Ave 1730, BR-05508 Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, SP, Brazil-
Descrição: dc.descriptionUniv Freiburg, Fac Med, Dept Hematol & Oncol, Freiburg, Germany-
Descrição: dc.descriptionHaraldsplass Deaconess Hosp, Dept Internal Med, Bergen, Norway-
Descrição: dc.descriptionSao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Inst Biomed Sci, Dept Microbiol, Vaccine Dev Lab, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Toronto, Krembil Res Inst, Univ Hlth Network, Toronto, ON, Canada-
Descrição: dc.descriptionUniv Toronto, Dept Med Biophys, Toronto, ON, Canada-
Descrição: dc.descriptionUniv Toronto, Dept Comp Sci, Toronto, ON, Canada-
Descrição: dc.descriptionUniv Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USA-
Descrição: dc.descriptionSeattle Childrens Res Inst, Seattle, WA USA-
Descrição: dc.descriptionUniversal Sci Educ & Res Network, Network Immun Infect Malignancy & Autoimmun, Sao Paulo, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2017/05264-7-
Descrição: dc.descriptionFAPESP: 2018/188869-
Descrição: dc.descriptionFAPESP: 2020/01688-0-
Descrição: dc.descriptionFAPESP: 2020/07069-0-
Descrição: dc.descriptionFAPESP: 2020/07972-1-
Descrição: dc.descriptionFAPESP: 2020/09146-1-
Descrição: dc.descriptionFAPESP: 13/50343-1-
Descrição: dc.descriptionCNPq: 311530/2019-2-
Descrição: dc.descriptionOntario Research Fund: 34876-
Descrição: dc.descriptionNatural Sciences Research Council: 203475-
Descrição: dc.descriptionCanada Foundation for Innovation: 29272-
Descrição: dc.descriptionCanada Foundation for Innovation: 225404-
Descrição: dc.descriptionCanada Foundation for Innovation: 33536-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format17-
Idioma: dc.languageen-
Publicador: dc.publisherAmer Soc Clinical Investigation Inc-
Relação: dc.relationJci Insight-
???dc.source???: dc.sourceWeb of Science-
Título: dc.titleThe relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2-infected patients by sex and age-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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