A Diagnostic Algorithm for Posterior Fossa Tumors in Children: A Validation Study

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorChildrens Hosp Philadelphia-
Autor(es): dc.contributorUCL-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorAlves, C. A. P. F.-
Autor(es): dc.creatorLobel, U.-
Autor(es): dc.creatorMartin-Saavedra, J. S.-
Autor(es): dc.creatorToescu, S.-
Autor(es): dc.creatorTsunemi, M. H. [UNESP]-
Autor(es): dc.creatorTeixeira, S. R.-
Autor(es): dc.creatorMankad, K.-
Autor(es): dc.creatorHargrave, D.-
Autor(es): dc.creatorJacques, T. S.-
Autor(es): dc.creatorCosta Leite, C. da-
Autor(es): dc.creatorGoncalves, F. G.-
Autor(es): dc.creatorVossough, A.-
Autor(es): dc.creatorD'Arco, F.-
Data de aceite: dc.date.accessioned2022-02-22T00:59:54Z-
Data de disponibilização: dc.date.available2022-02-22T00:59:54Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-04-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3174/ajnr.A7057-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210428-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210428-
Descrição: dc.descriptionBACKGROUND AND PURPOSE: Primary posterior fossa tumors comprise a large group of neoplasias with variable aggressiveness and short and long-term outcomes. This study aimed to validate the clinical usefulness of a radiologic decision flow chart based on previously published neuroradiologic knowledge for the diagnosis of posterior fossa tumors in children. MATERIALS AND METHODS: A retrospective study was conducted (from January 2013 to October 2019) at 2 pediatric referral centers, Children?s Hospital of Philadelphia, United States, and Great Ormond Street Hospital, United Kingdom. Inclusion criteria were younger than 18 years of age and histologically and molecularly confirmed posterior fossa tumors. Subjects with no available preoperative MR imaging and tumors located primarily in the brain stem were excluded. Imaging characteristics of the tumors were evaluated following a predesigned, step-by-step flow chart. Agreement between readers was tested with the Cohen ?, and each diagnosis was analyzed for accuracy. RESULTS: A total of 148 cases were included, with a median age of 3.4?years (interquartile range, 2.1?6.1 years), and a male/female ratio of 1.24. The predesigned flow chart facilitated identification of pilocytic astrocytoma, ependymoma, and medulloblastoma sonic hedgehog tumors with high sensitivity and specificity. On the basis of the results, the flow chart was adjusted so that it would also be able to better discriminate atypical teratoid/rhabdoid tumors and medulloblastoma groups 3 or 4 (sensitivity = 75%?79%; specificity = 92%?99%). Moreover, our adjusted flow chart was useful in ruling out ependymoma, pilocytic astrocytomas, and medulloblastoma sonic hedgehog tumors. CONCLUSIONS: The modified flow chart offers a structured tool to aid in the adjunct diagnosis of pediatric posterior fossa tumors. Our results also establish a useful starting point for prospective clinical studies and for the development of automated algorithms, which may provide precise and adequate diagnostic tools for these tumors in clinical practice.-
Descrição: dc.descriptionChildrens Hosp Philadelphia, Div Neuroradiol, Dept Radiol, 3401 Civ Ctr Blvd, Philadelphia, PA 19104 USA-
Descrição: dc.descriptionUCL, Great Ormond St Hosp Children, Dept Radiol, London, England-
Descrição: dc.descriptionUCL, Great Ormond St Hosp Children, Dept Neurosurg, London, England-
Descrição: dc.descriptionSao Paulo State Univ, Dept Biostat, Inst Biociencias, Sao Paulo, Brazil-
Descrição: dc.descriptionUCL, Great Ormond St Inst Child Hlth, Dev Biol & Canc Programme, London, England-
Descrição: dc.descriptionHosp Clin Sao Paulo, Fac Med Sao Paulo, Dept Radiol, Sao Paulo, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Biostat, Inst Biociencias, Sao Paulo, Brazil-
Formato: dc.format961-968-
Idioma: dc.languageen-
Publicador: dc.publisherAmer Soc Neuroradiology-
Relação: dc.relationAmerican Journal Of Neuroradiology-
???dc.source???: dc.sourceWeb of Science-
Título: dc.titleA Diagnostic Algorithm for Posterior Fossa Tumors in Children: A Validation Study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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