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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Federal de São Carlos (UFSCar) | - |
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.contributor | Univ Bern | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Pela, Vinicius Taioqui | - |
Autor(es): dc.creator | Rabelo Buzalaf, Marilia Afonso | - |
Autor(es): dc.creator | Niemeyer, Samira Helena | - |
Autor(es): dc.creator | Baumann, Tommy | - |
Autor(es): dc.creator | Henrique-Silva, Flavio | - |
Autor(es): dc.creator | Toyama, Danyelle | - |
Autor(es): dc.creator | Crusca, Edson [UNESP] | - |
Autor(es): dc.creator | Marchetto, Reinaldo [UNESP] | - |
Autor(es): dc.creator | Lussi, Adrian | - |
Autor(es): dc.creator | Carvalho, Thiago Saads | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:59:53Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:59:53Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-04-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1016/j.jdent.2021.103612 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/210426 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/210426 | - |
Descrição: dc.description | Objective: This study investigated the mechanism of action of different proteins/peptides (separately or in combination), focusing on how they act directly on the native enamel surface and on modifying the salivary pellicle. Methods: A total of 170 native human enamel specimens were prepared and submitted to different treatments (2 h; 37 degrees C): with deionized water, CaneCPI-5, Hemoglobin, Statherin, or a combination of all three proteins/peptides. The groups were subdivided into treatment acting on the enamel surface (NoP - absence of salivary pellicle), and treatment modifying the salivary pellicle (P). Treatment was made (2 h; 37 degrees C) in all specimens, and later, for P, the specimens were incubated in human saliva (2 h; 37 degrees C). In both cases, the specimens were immersed in 1% citric acid (pH 3.6; 2 min; 25 degrees C). Calcium released from enamel (CaR) and its relative surface reflection intensity (%SRI) was measured after 5 cycles. Between-group differences were verified with two-way ANOVA, with presence of pellicle and treatment as factors (alpha = 0.05). Results: The presence of pellicle provided better protection regarding %SRI (p < 0.01), but not regarding CaR (p = 0.201). In relation to treatment, when compared to the control group, all proteins/peptides provided significantly better protection (p < 0.01 for %SRI and Car). The combination of all three proteins/peptides demonstrated the best protective effect (p < 0.01 for %SRI). Conclusion: Depending on the protein or peptide, its erosion-inhibiting effect derives from their interaction with the enamel surface or from modifying the pellicle, so a combination of proteins and peptides provides the best protection. Clinical significance: The present study opens a new direction for a possible treatment with a combination of proteins for native human enamel, which can act directly on the enamel surface as well on the modification of the salivary pellicle, for the prevention of dental erosion. | - |
Descrição: dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
Descrição: dc.description | Univ Fed Sao Carlos, Dept Genet & Evolut, Sao Carlos, SP, Brazil | - |
Descrição: dc.description | Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, SP Al Octavio Pinheiro Brisolla 9-75, BR-17012901 Bauru, SP, Brazil | - |
Descrição: dc.description | Univ Bern, Sch Dent Med, Dept Restorat Prevent & Pediat Dent, Bern, Switzerland | - |
Descrição: dc.description | Univ Estadual Paulista, Chem Inst, Araraquara, SP, Brazil | - |
Descrição: dc.description | Univ Estadual Paulista, Chem Inst, Araraquara, SP, Brazil | - |
Descrição: dc.description | FAPESP: 2019/08437-5 | - |
Formato: dc.format | 7 | - |
Idioma: dc.language | en | - |
Publicador: dc.publisher | Elsevier B.V. | - |
Relação: dc.relation | Journal Of Dentistry | - |
???dc.source???: dc.source | Web of Science | - |
Palavras-chave: dc.subject | Acquired pellicle | - |
Palavras-chave: dc.subject | Dental erosion | - |
Palavras-chave: dc.subject | Enamel | - |
Palavras-chave: dc.subject | Protein | - |
Palavras-chave: dc.subject | Pellicle modification | - |
Palavras-chave: dc.subject | saliva | - |
Título: dc.title | Acquired pellicle engineering with proteins/peptides: Mechanism of action on native human enamel surface | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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