Spray-dried bacterial cellulose nanofibers: A new generation of pharmaceutical excipient intended for intestinal drug delivery

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniv Araraquara-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorSo Paulo State Univ-
Autor(es): dc.creatorMeneguin, Andreia Bagliotti [UNESP]-
Autor(es): dc.creatorBarud, Hernane da Silva-
Autor(es): dc.creatorSabio, Rafael Miguel [UNESP]-
Autor(es): dc.creatorSousa, Paula Zanin de-
Autor(es): dc.creatorManieri, Karyn Fernanda [UNESP]-
Autor(es): dc.creatorPedro de Freitas, Luis Alexandre-
Autor(es): dc.creatorPacheco, Guilherme-
Autor(es): dc.creatorAlonso, Jovan Duran-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:59:45Z-
Data de disponibilização: dc.date.available2022-02-22T00:59:45Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.carbpol.2020.116838-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210409-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210409-
Descrição: dc.descriptionDefibrillation of bacterial cellulose by ultra-refining was efficient to release nanofibers (BCNF) which were spray dried with the matrices formers mannitol (MN), maltodextrin or hydroxypropylmethylcellulose. The best microsystem comprised the association of BCNF and MN, so the selected microparticles were loaded with diclofenac sodium or caffeine. Depending on the proportion of BCNF, the nanofibers collapse promoted by spray drying can occur onto surface or into microparticles core, leading to different release behaviors. Samples showed pH-dependent drug release, so the microsystem developed with the lowest BCNF concentration showed important trend to gastroresistance. Caffeine was spray dried as a free drug and for this reason it was devoid of any control over release rates. The set of results showed BCNF can be considered an interesting and potential pharmaceutical excipient for lipophilic drugs. Beyond that, BCNF association with MN can lead to novel enteric drug delivery systems based on natural polymers.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLNNano-
Descrição: dc.descriptionSao Paulo State Univ, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Araraquara, Lab Biopolymers & Biomat, BR-14801320 Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil-
Descrição: dc.descriptionSo Paulo State Univ, Analyt Chem Dept, BR-14801970 Araraquara, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2016/08435-4-
Descrição: dc.descriptionFAPESP: 2018/25512-8-
Descrição: dc.descriptionLNNano: SEM-C2-25397-
Formato: dc.format13-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationCarbohydrate Polymers-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectIntestinal drug delivery-
Palavras-chave: dc.subjectPharmaceutical excipients-
Palavras-chave: dc.subjectBacterial cellulose nanofibers-
Palavras-chave: dc.subjectSpray drying-
Título: dc.titleSpray-dried bacterial cellulose nanofibers: A new generation of pharmaceutical excipient intended for intestinal drug delivery-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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