Antivirulence activity and in vivo efficacy of a thiazole derivative against candidiasis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorSUNY Stony Brook-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniv Guarulhos-
Autor(es): dc.creatorSa, Nivea Pereira de-
Autor(es): dc.creatorBarros, Patricia Pimentel de [UNESP]-
Autor(es): dc.creatorJunqueira, Juliana Campos [UNESP]-
Autor(es): dc.creatorValerio, Aline Dias-
Autor(es): dc.creatorLino, Cleudiomar Inacio-
Autor(es): dc.creatorOliveira, Renata Barbosa de-
Autor(es): dc.creatorRosa, Carlos Augusto-
Autor(es): dc.creatorJohann, Susana-
Data de aceite: dc.date.accessioned2022-02-22T00:59:42Z-
Data de disponibilização: dc.date.available2022-02-22T00:59:42Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.mycmed.2021.101134-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210394-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210394-
Descrição: dc.descriptionCandida albicans is a pathogen equipped with a variety of commensal and virulence traits that help it colonize the microbiota and invade host tissue during infection. In this study, we investigated the potential anticandidal activity of 3-[2-(4-(4-methoxyphenyl)thiazol-2-yl)hydrazino)]butan-1-ol (MT), a thiazolylhydrazone compound synthesized by our group, and identified it as a promising antifungal agent. The activity of MT was evaluated in vitro and in vivo against C. albicans as well as its ability to inhibit virulence factors. For this, the ability of MT to inhibit the adhesion of C. albicans to human buccal epithelial cells and biofilm formation and filamentation was tested. In addition, the potential in vivo activity of MT was evaluated in murine models of oral candidiasis. Our results confirmed the antifungal activity of MT, with a minimal inhibitory concentration range of 0.5-2 mg/mL. Indeed, MT treatment in vitro decreased the expression of C. albicans genes involved in biofilm formation and morphogenesis and encoding hydrolytic enzymes, which was also confirmed through phenotypic observations. In addition, MT promoted a decrease in the colony forming units recovered from the tongues of mice with oral candidiasis. In this work, we present a potent antivirulence compound that shows potential for candidiasis therapy, especially for topical use. (C) 2021 Elsevier Masson SAS. All rights reserved.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionPro-Reitoria de Pesquisa da UFMG-
Descrição: dc.descriptionUniv Fed Minas Gerais, Inst Ciencias Biol, Dept Microbiol, Av Antonio Carlos 6627,POB 486, BR-31270901 Belo Horizonte, MG, Brazil-
Descrição: dc.descriptionSUNY Stony Brook, Dept Microbiol & Immunol, Stony Brook, NY USA-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Biociencias & Diagnost Bucal, Inst Ciencia & Tecnol, Sao Jose Dos Campos, SP, Brazil-
Descrição: dc.descriptionUniv Fed Minas Gerais, Fac Farm, Dept Prod Farmaceut, Belo Horizonte, MG, Brazil-
Descrição: dc.descriptionUniv Guarulhos, Postgrad Program Nursing, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Biociencias & Diagnost Bucal, Inst Ciencia & Tecnol, Sao Jose Dos Campos, SP, Brazil-
Formato: dc.format6-
Idioma: dc.languageen-
Publicador: dc.publisherMasson Editeur-
Relação: dc.relationJournal De Mycologie Medicale-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectAntifungal-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectThiazole-
Palavras-chave: dc.subjectVirulence-
Palavras-chave: dc.subjectBiofilm-
Palavras-chave: dc.subjectFilamentation-
Título: dc.titleAntivirulence activity and in vivo efficacy of a thiazole derivative against candidiasis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.