Functions of the GABAergic system on serum LH concentrations in pre-pubertal Nellore heifers

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorSao Paulo Agcy Agribusiness Technol-
Autor(es): dc.contributorTexas A&M Univ-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorCardoso, Daniel-
Autor(es): dc.creatorCardoso, Rodolfo C.-
Autor(es): dc.creatorNogueira, Guilherme de Paula [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:59:40Z-
Data de disponibilização: dc.date.available2022-02-22T00:59:40Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.anireprosci.2021.106764-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210374-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210374-
Descrição: dc.descriptionThis study was conducted to evaluate the luteinizing hormone (LH) secretion pattern after gamma-aminobutyric acid (GABA(A)) antagonist to determine the effects of the GABAergic system on LH secretion during reproductive maturation in pre-pubertal Nellore heifers. Nellore heifers (n = 10) were administered a picrotoxin injection of 0.18 mg/kg, i.v. Blood samples were collected every 15 min for 3 h at different developmental stages (8, 10, 14 and 17 mo of age). Plasma concentrations of LH were quantified using an RIA (sensitivity of 0.04 ng/mL and CV of 15 %). There was an interaction between treatment and age (P = 0.034). Picrotoxin-treated heifers had lesser (P <= 0.05) LH mean concentrations during a 3 h period at 10 and 17 mo of age compared to control heifers (P <= 0.05). Comparing the period before and after Picrotoxin injection in the same animals, there was a 33 % decrease in LH concentration at 8 mo of age (P = 0.0165). These results indicate the GABAergic system has a stimulatory function in inducing LH secretion in pre-pubertal Nellore heifers. These findings corroborate previous results that GABA increases GnRH/LH secretion in other species during the pre-pubertal period.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSao Paulo Agcy Agribusiness Technol, Secretary Agr & Food Supply, Biol Inst, Sao Paulo, Brazil-
Descrição: dc.descriptionTexas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA-
Descrição: dc.descriptionSao Paulo State Univ, Dept Anim Prod & Hlth, Aracatuba, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Anim Prod & Hlth, Aracatuba, Brazil-
Descrição: dc.descriptionFAPESP: 99/10446-7-
Formato: dc.format6-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationAnimal Reproduction Science-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectHypothalamus-
Palavras-chave: dc.subjectNeuroendocrine-
Palavras-chave: dc.subjectPicrotoxin-
Palavras-chave: dc.subjectPuberty-
Palavras-chave: dc.subjectSexual maturation-
Título: dc.titleFunctions of the GABAergic system on serum LH concentrations in pre-pubertal Nellore heifers-
Tipo de arquivo: dc.typelivro digital-
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