Combined photodynamic therapy with chloroaluminum phthalocyanine and doxorubicin nanoemulsions in breast cancer model

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorCabral, Agata Silva [UNESP]-
Autor(es): dc.creatorRivas Leonel, Ellen Cristina [UNESP]-
Autor(es): dc.creatorCandido, Natalia Maria [UNESP]-
Autor(es): dc.creatorPiva, Henrique Luis-
Autor(es): dc.creatorMelo, Maryanne Trafani de-
Autor(es): dc.creatorTaboga, Sebastiao Roberto [UNESP]-
Autor(es): dc.creatorRahal, Paula [UNESP]-
Autor(es): dc.creatorTedesco, Antonio Claudio-
Autor(es): dc.creatorCalmon, Marilia Freitas [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:59:28Z-
Data de disponibilização: dc.date.available2022-02-22T00:59:28Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jphotobiol.2021.112181-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210309-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210309-
Descrição: dc.descriptionBreast cancer is the most common neoplasm among women but thanks to innovative therapies, patients' prognosis has considerably improved. In this aspect, nanotechnology has been applied for cancer therapy aiming to reduce its usual side effects. In this study we aimed to evaluate the effects of nanoemulsions containing photosensitizer and chemotherapeutic agents associated with photodynamic therapy in a breast cancer in vivo model. Our results showed that synergistic treatments in which chloroaluminum phthalocyanine (NE-Pc) administered together with Doxorubicin (Dox) in the presence of laser irradiation (NE-PcDoxo + PDT) led to a reduction of 4 T1 induced breast cancer in mice, decline of tumor VEGF expression, increase in Caspase-3 expression, tissue necrosis and massive decrease in proliferative cells, as shown by Ki67 immunostaining. Furthermore, this associated treatment induced overexpression of apoptotic genes ABL1, CD70, CRADD, FASL, and NME5 and a reduction in expression of anticancer drug target genes CDK2, ERBB2, FIGF, IGF2, PARP4 and PGR. These results validate this treatment as a promising alternative to improve the currently applied anticancer strategies.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionProject PRONON-SIPAR-
Descrição: dc.descriptionSao Paulo State Univ, Lab Genom Studies, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Lab Microscopy & Microanal, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Ctr Nanotechnol & Tissue Engn, Chem Dept, Photobiol & Photomed Res Grp, BR-14040901 Ribeirao Preto, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Lab Genom Studies, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Lab Microscopy & Microanal, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2013/50181-1-
Descrição: dc.descriptionFAPESP: 2020/04009-6-
Descrição: dc.descriptionProject PRONON-SIPAR: 25000.077093/201586-
Formato: dc.format10-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationJournal Of Photochemistry And Photobiology B-biology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectAlternative therapy-
Palavras-chave: dc.subjectAnticancer treatment-
Palavras-chave: dc.subjectBreast cancer-
Palavras-chave: dc.subjectNanotechnology-
Palavras-chave: dc.subjectPDT-
Palavras-chave: dc.subjectPhotosensitizer-
Título: dc.titleCombined photodynamic therapy with chloroaluminum phthalocyanine and doxorubicin nanoemulsions in breast cancer model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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