Antiarthritic and Antinociceptive Potential of Ethanolic Extract from Leaves of Doliocarpus dentatus (Aubl.) Standl. in Mouse Model

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Autor(es): dc.contributorFed Univ Grande Dourados-
Autor(es): dc.contributorUniversidade Estadual de Mato Grosso do Sul (UEMS)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorBranquinho, Lidiane Schultz-
Autor(es): dc.creatorVerdan, Maria Helena-
Autor(es): dc.creatorSilva-Filho, Saulo Euclides-
Autor(es): dc.creatorOliveira, Rodrigo Juliano-
Autor(es): dc.creatorCardoso, Claudia Andrea Lima-
Autor(es): dc.creatorArena, Arielle Cristina [UNESP]-
Autor(es): dc.creatorKassuya, Candida Aparecida Leite-
Data de aceite: dc.date.accessioned2022-02-22T00:59:25Z-
Data de disponibilização: dc.date.available2022-02-22T00:59:25Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.4103/pr.pr_79_20-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210295-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210295-
Descrição: dc.descriptionObjectives: The folk use of Doliocarpus dentatus for pain and inflammatory conditions led our group to evaluate the anti-inflammatory, antinociceptive, and antiarthritic effects of its ethanol extract from the leaves (EEDd) on mouse models. Results: Oral treatments with EEDd (100-300 mg/kg) significantly inhibited the formalin-induced nociceptive and cold sensitivity, prevented acetic acid-induced nociceptive behavior, and prevented articular inflammation (including knee edema, leukocyte infiltration, and mechanical hyperalgesia) induced by zymosan. In the peritonitis model, betulinic acid (BA, 0.3-30 mg/kg) and EEDd (300 mg/kg) significantly inhibited zymosan-induced leukocyte infiltration. In the complete Freund adjuvant (CFA) model, oral treatments with EEDd (100-300 mg/kg) for 21 days significantly inhibited mechanical hyperalgesia, cold response, and edema. In the MTT viability assay, EEDd (3-90 mu g/mL) did not induce leukocytes cytotoxicity. cytotoxicity. Most models employed male and female Swiss mice or, for the CFA test, C57BL/6 mice. Conclusion: This study demonstrates that EEDd exhibited antinociceptive, antihyperalgesic, and antiarthritic potential in mice and BA contribute for the EEDd observed activities.-
Descrição: dc.descriptionFed Univ Grande Dourados, Fac Hlth Sci, Dourados, MS, Brazil-
Descrição: dc.descriptionFed Univ Grande Dourados, Postgrad Program Chem, Fac Exact Sci & Technol, Dourados, MS, Brazil-
Descrição: dc.descriptionUniv Estadual Mato Grosso do Sul, Ctr Studies Nat Resources, Dourados, MS, Brazil-
Descrição: dc.descriptionUniv Fed Mato Grosso do Sul, Fac Pharmaceut Sci, Campo Grande, MS, Brazil-
Descrição: dc.descriptionUniv Fed Mato Grosso do Sul, Fac Med FAMED Dr Helio Mandetta, Campo Grande, MS, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Inst Biosci Botucatu, Dept Morphol, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Inst Biosci Botucatu, Dept Morphol, Botucatu, SP, Brazil-
Formato: dc.format28-33-
Idioma: dc.languageen-
Publicador: dc.publisherWolters Kluwer Medknow Publications-
Relação: dc.relationPharmacognosy Research-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectArthritis-
Palavras-chave: dc.subjectarticular inflammation-
Palavras-chave: dc.subjectbetulinic acid-
Palavras-chave: dc.subjectDoliocarpus dentatus-
Palavras-chave: dc.subjectpain-
Título: dc.titleAntiarthritic and Antinociceptive Potential of Ethanolic Extract from Leaves of Doliocarpus dentatus (Aubl.) Standl. in Mouse Model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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