Genome-wide association study between copy number variation regions and carcass- and meat-quality traits in Nellore cattle

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniv Guelph-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUSDA ARS-
Autor(es): dc.contributorUniv Maryland-
Autor(es): dc.creatorBerton, Mariana Piatto [UNESP]-
Autor(es): dc.creatorAntunes Lemos, Marcos Vinicius de [UNESP]-
Autor(es): dc.creatorSeleguim Chud, Tatiane Cristina-
Autor(es): dc.creatorBonvino Stafuzza, Nedenia [UNESP]-
Autor(es): dc.creatorKluska, Sabrina [UNESP]-
Autor(es): dc.creatorAmorim, Sabrina Thaise [UNESP]-
Autor(es): dc.creatorSilva Ferlin Lopes, Lucas [UNESP]-
Autor(es): dc.creatorCravo Pereira, Angelica Simone-
Autor(es): dc.creatorBickhart, Derek-
Autor(es): dc.creatorLiu, George-
Autor(es): dc.creatorGalvao de Albuquerque, Lucia [UNESP]-
Autor(es): dc.creatorBaldi, Fernando [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:59:22Z-
Data de disponibilização: dc.date.available2022-02-22T00:59:22Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-04-27-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1071/AN20275-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210274-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210274-
Descrição: dc.descriptionContext. Indicine breeds are the main source of beef products in tropical and subtropical regions. However, genetic improvement for carcass- and meat-quality traits in zebu cattle have been limited and genomics studies concerning structural variations that influence these traits are essential. Aim. The aim of this study was to perform a genome-wide association study between copy number variation regions (CNVRs) and carcass- and meat quality-traits in Nellore cattle. Methods. In total, 3794 animals, males and females included, were genotyped using a 777 962 single-nucleotide polymorphism platform of BovineHD BeadChip (777k; Illumina Inc.). Of these, 1751 Nellore bulls were slaughtered at 24 months of age for further carcass beef analysis. The following traits were studied: beef tenderness, marbling, rib-eye area, backfat thickness and meat colour (lightness, redness and yellowness). The CNV detection was conducted through PennCNV software. The association analyses were performed using CNVRuler software. Key results. Several identified genomic regions were linked to quantitative trait loci associated with fat deposition (FABP7) and lipid metabolism (PPARA; PLA2 family; BCHE), extracellular matrix (INS; COL10A1), contraction (SLC34A3; TRDN) and muscle development (CAPZP). The gene-enrichment analyses highlighted biological mechanisms directly related to the metabolism and synthesis of lipids and fatty acids. Conclusions. The large number of potential candidate genes identified within the CNVRs, as well as the functions and pathways identified, should help better elucidate the genetic mechanisms involved in the expression of beef and carcass traits in Nellore cattle. Several CNVRs harboured genes that might have a functional impact to improve the beef and carcass traits. Implications. The results obtained contribute to upgrade the sensorial and organoleptic attributes of Nellore cattle and make feasible the genetic improvement of carcass- and meat-quality traits.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Zootecnia, Fac Ciencias Agr & Vet, Via Acesso Prof Paulo Donato Castellane, BR-14884900 Jaboticabal, SP, Brazil-
Descrição: dc.descriptionUniv Guelph, Ctr Genet Improvement Livestock, 50 Stone Rd East,Bldg 70, Guelph, ON N1G 2W1, Canada-
Descrição: dc.descriptionUniv Sao Paulo, Fac Zootecnia & Engn Alimentos, Rua Duque Caxias Norte 225, BR-13635900 Pirassununga, SP, Brazil-
Descrição: dc.descriptionUSDA ARS, ANRI, Bovine Funct Genom Lab, Beltsville, MD 20705 USA-
Descrição: dc.descriptionUniv Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Zootecnia, Fac Ciencias Agr & Vet, Via Acesso Prof Paulo Donato Castellane, BR-14884900 Jaboticabal, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2009/16118-5-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format731-744-
Idioma: dc.languageen-
Publicador: dc.publisherCsiro Publishing-
Relação: dc.relationAnimal Production Science-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectbeef cattle-
Palavras-chave: dc.subjectBos indicus-
Palavras-chave: dc.subjectmeat quality traits-
Palavras-chave: dc.subjectcarcass composition-
Palavras-chave: dc.subjectgenomics-
Título: dc.titleGenome-wide association study between copy number variation regions and carcass- and meat-quality traits in Nellore cattle-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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