Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Federal de São Carlos (UFSCar) | - |
Autor(es): dc.contributor | Univ Colorado | - |
Autor(es): dc.contributor | Hosp Clin Porto Alegre | - |
Autor(es): dc.contributor | Universidade Federal de Minas Gerais (UFMG) | - |
Autor(es): dc.contributor | Pontificia Univ Catolica Rio Grande do Sul | - |
Autor(es): dc.contributor | Global Res & Innovat Network GRINN | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Brandao, Gustavo Mucoucah Sampaio | - |
Autor(es): dc.creator | Malgor, Rafael D. | - |
Autor(es): dc.creator | Vieceli, Tarsila | - |
Autor(es): dc.creator | Candido, Raissa Carolina Fonseca | - |
Autor(es): dc.creator | Inacio, Jose Francisco Secorun | - |
Autor(es): dc.creator | Rodrigues, Clarissa Garcia | - |
Autor(es): dc.creator | Malgor, Emily A. | - |
Autor(es): dc.creator | Sobreira, Marcone Lima [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:59:07Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:59:07Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-04-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1177/17085381211002726 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/210188 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/210188 | - |
Descrição: dc.description | Introduction Treatment of cancer-associated venous thromboembolism (CAVTE) remains challenging. The aim of this study was to assess the outcomes of direct acting oral anticoagulants (DOAs) for the treatment of CAVTE. Materials and methods A network meta-analysis of randomized clinical trials comparing DOAs (Apixaban, Rivaroxaban, and Edoxaban) versus Dalteparin for the treatment of CAVTE was performed. Outcomes of interest included, VTE recurrence, all-cause mortality, event-free survival, major bleeding, and clinically relevant non-major bleeding (CRNMB). Analysis was based on a random effects model and Bayesian Markov-chain Monte Carlo method was used for indirect comparisons. Results Four RCTs involving 2894 patients were included. Overall certainty of evidence was moderate regarding all outcomes. DOAs exhibited lower risk of VTE (RR 0.62; 95% CI 0.44, 0.87; P = 0.007), similar risk of major bleeding (RR 1.33; 95% CI 0.84, 2.11; P = 0.23), and higher risk of CRNMB (RR 1.66, 95% CI 1.08, 2.56; P = 0.02), compared with Dalteparin. Risk of all-cause mortality and event-free survival were similar between groups with RR 0.99 (95% CI 0.84, 1.16) and RR 1.03 (95% CI 0.94, 1.13), respectively. Apixaban ranked first for recurrent VTE (42.4%) and major bleeding (62.3%) and Dalteparin ranked first for CRNMB (54.7%). Rivaroxaban ranked best considering all-cause mortality (58.7%); Apixaban ranked best for event-free survival (83.6%). Conclusions DOAs presented a reduced risk of recurrent VTE with similar risk of major bleeding compared to Dalteparin. However, a higher risk of CRNMB is expected when this cohort of patients are treated with DOAs instead of Dalteparin. | - |
Descrição: dc.description | Univ Fed Sao Carlos, Dept Med, Sao Carlos Campus, Sao Carlos, Brazil | - |
Descrição: dc.description | Univ Colorado, Anschutz Med Ctr, Aurora, CO USA | - |
Descrição: dc.description | Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil | - |
Descrição: dc.description | Univ Fed Minas Gerais, Fac Pharm, Belo Horizonte Campus, Belo Horizonte, MG, Brazil | - |
Descrição: dc.description | Pontificia Univ Catolica Rio Grande do Sul, Porto Alegre, RS, Brazil | - |
Descrição: dc.description | Global Res & Innovat Network GRINN, Joinville, SC, Brazil | - |
Descrição: dc.description | Sao Paulo State Univ, Med Sch, Div Vasc & Endovasc Surg, Botucatu Campus, Botucatu, SP, Brazil | - |
Descrição: dc.description | Sao Paulo State Univ, Med Sch, Div Vasc & Endovasc Surg, Botucatu Campus, Botucatu, SP, Brazil | - |
Formato: dc.format | 16 | - |
Idioma: dc.language | en | - |
Publicador: dc.publisher | Sage Publications Ltd | - |
Relação: dc.relation | Vascular | - |
???dc.source???: dc.source | Web of Science | - |
Palavras-chave: dc.subject | Direct oral anticoagulants | - |
Palavras-chave: dc.subject | venous thromboembolism | - |
Palavras-chave: dc.subject | cancer | - |
Título: dc.title | A network meta-analysis of direct factor Xa inhibitors for the treatment of cancer-associated venous thromboembolism | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: