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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.contributor | Univ Tecnol Fed Parana | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Univ Republ UDELAR | - |
Autor(es): dc.creator | Trape, Atila Alexandre | - |
Autor(es): dc.creator | Rodrigues, Jhennyfer Aline Lima | - |
Autor(es): dc.creator | Ferezin, Leticia Perticarrara | - |
Autor(es): dc.creator | Ferrari, Gustavo Duarte | - |
Autor(es): dc.creator | Lizzi, Elisangela Aparecida da Silva | - |
Autor(es): dc.creator | Moraes, Vitor Nolasco de | - |
Autor(es): dc.creator | Silva, Roberta Fernanda da [UNESP] | - |
Autor(es): dc.creator | Zago, Anderson Saranz [UNESP] | - |
Autor(es): dc.creator | Brazo-Sayavera, Javier | - |
Autor(es): dc.creator | Bueno Junior, Carlos Roberto | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:58:41Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:58:41Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-03-10 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.3389/fphys.2021.566023 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/210146 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/210146 | - |
Descrição: dc.description | Associations of endothelial nitric oxide synthase (NOS3) polymorphisms with hypertension and response to exercise training in prehypertensive and hypertensive older adult women remain unclear. This study used a multicomponent program (various capacities and motor skills) in the physical training intervention. It analyzed the influence of NOS3 polymorphisms [-786T > C, 894G > T (Glu298Asp), and intron 4b/a] on the response of blood pressure (BP), nitrite concentration, and physical fitness in older adult women. Fifty-two participants aged between 50 and 80 underwent body mass index, BP, 6-min walk, elbow flexion, and sit and stand-up tests to assess physical fitness. The intervention duration was 12 weeks, twice a week, on non-consecutive days. Each session lasted 90 min, maintaining an intensity between 13 (moderate) and 15 (intense), controlled by the Subjective Effort Perception Scale. Plasma/blood samples were collected to assess nitrite concentration and genotyping. The statistical analysis included Fisher's exact test and linear mixed-effects models. The multicomponent training's positive effect was observed with a similar response in both prehypertensive and hypertensive groups. However, carriers of different genotypes demonstrated different responses to training: the decreases in systolic and diastolic BP and increases in nitrite expected from the physical training were smaller in variant genotype than ancestral genotype carriers, especially in the hypertensive group. At positions -786T > C and Glu298Asp, only the ancestral genotypes showed a decrease in diastolic BP (Delta% = -8.1, and Delta% = -6.5, respectively) and an increase on nitrite (Delta% = 19.1, and Delta% = 24.1, respectively) in the hypertensive group. Our results show that the benefits of a multicomponent training intervention seem to be genotype-dependent. It should be possible to consider genetic variants when selecting an exercise treatment intervention. | - |
Descrição: dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
Descrição: dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
Descrição: dc.description | Univ Sao Paulo, Ribeirao Preto Coll Nursing, Ribeirao Preto, Brazil | - |
Descrição: dc.description | Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Ribeirao Preto, Brazil | - |
Descrição: dc.description | Univ Sao Paulo, Ribeirao Preto Med Sch, Ribeirao Preto, Brazil | - |
Descrição: dc.description | Univ Tecnol Fed Parana, Acad Dept Math, Cornelio Procopio, Brazil | - |
Descrição: dc.description | Sao Paulo State Univ, Dept Phys Educ, Bauru, SP, Brazil | - |
Descrição: dc.description | Univ Republ UDELAR, Polo Desarrollo Univ EFISAL, Ctr Univ Reg Noreste, Rivera, Uruguay | - |
Descrição: dc.description | Sao Paulo State Univ, Dept Phys Educ, Bauru, SP, Brazil | - |
Descrição: dc.description | FAPESP: 2013/21159-8 | - |
Descrição: dc.description | CNPq: 485045/2013-3 | - |
Formato: dc.format | 12 | - |
Idioma: dc.language | en | - |
Publicador: dc.publisher | Frontiers Media Sa | - |
Relação: dc.relation | Frontiers In Physiology | - |
???dc.source???: dc.source | Web of Science | - |
Palavras-chave: dc.subject | aging | - |
Palavras-chave: dc.subject | exercise training | - |
Palavras-chave: dc.subject | genotype | - |
Palavras-chave: dc.subject | nitric oxide | - |
Palavras-chave: dc.subject | physical activity | - |
Título: dc.title | NOS3 Polymorphisms Can Influence the Effect of Multicomponent Training on Blood Pressure, Nitrite Concentration and Physical Fitness in Prehypertensive and Hypertensive Older Adult Women | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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