The Influence of Pregnancy on Female Prostate Morphophysiology in Gerbils (Meriones unguiculatus)

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Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorGomes, Lorranny de Jesus-
Autor(es): dc.creatorRodrigues, Giovanna Amaral-
Autor(es): dc.creatorMalmann Medeiros, Barbara Costa-
Autor(es): dc.creatorManso, Luana Araujo-
Autor(es): dc.creatorRamos, Jordana Gomes-
Autor(es): dc.creatorAzevedo Brito, Pedro Vale de-
Autor(es): dc.creatorTaboga, Sebastiao Roberto [UNESP]-
Autor(es): dc.creatorCarvalho, Hernandes Faustino de-
Autor(es): dc.creatorAlcantara dos Santos, Fernanda Cristina-
Autor(es): dc.creatorBiancardi, Manoel Francisco-
Data de aceite: dc.date.accessioned2022-02-22T00:58:22Z-
Data de disponibilização: dc.date.available2022-02-22T00:58:22Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-02-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s43032-021-00475-9-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210045-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210045-
Descrição: dc.descriptionMorphophysiological changes of the female prostate during pregnancy are still little known. Considering that this gland is highly influenced by steroid hormones, the aim of this study was to evaluate the impact of the pregnancy on female prostate morphophysiology in gerbils. Pregnant females were timed, and the prostates were analyzed at pregnancy days 6 (P6), 12 (P12), 18 (P18), and 24 (P24). Virgin females were used as the control group (C). We observed a profound change in the hormonal profile during gestation, which was marked by a high oscillation of the progesterone (P4) hormone. P4 serum levels increased, peaking at the middle of gestation, and decreased to the end of the pregnancy. The morphology of the gland in pregnant females also changed, being marked by an increase of acini lumen, and a decrease in stroma. Indeed, the acinar changes during pregnancy were followed by a significant reduction of the epithelial height, besides a change of the smooth muscle cells' morphology that became more relaxed. The number of progesterone receptor (PR) and androgen receptor (AR)-positives cells decreased with the increase of progesterone serum levels, showing an inverse relationship. Finally, we observed a reduction of epithelial proliferation and a significant increase of gland PAS-positive secretion at the end of pregnancy. Altogether, these results showed, for the first time, that the female prostate morphophysioloy is profoundly influenced by the gestational period, suggesting that the fluctuation of the P4 serum levels is the main factor influencing the gland during this period.-
Descrição: dc.descriptionFundacao de Amparo a Pequisa do Estado de Goias -Brazil (FAPEG)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUniv Fed Goias, Dept Histol Embryol & Cell Biol, Microscopy Lab Appl Reprod, Av Esperanca S-N,Campus Samambaia, BR-74690900 Goiania, Go, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Biol, Sao Jose Do Rio Preto, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Campinas, Dept Struct & Funct Biol, Campinas, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Biol, Sao Jose Do Rio Preto, SP, Brazil-
Descrição: dc.descriptionFundacao de Amparo a Pequisa do Estado de Goias -Brazil (FAPEG): 08/2018-
Descrição: dc.descriptionCNPq: 422302/2018-0-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format12-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer-
Relação: dc.relationReproductive Sciences-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectFemale prostate-
Palavras-chave: dc.subjectProgesterone-
Palavras-chave: dc.subjectGerbil-
Palavras-chave: dc.subjectPregnancy-
Título: dc.titleThe Influence of Pregnancy on Female Prostate Morphophysiology in Gerbils (Meriones unguiculatus)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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