Promising potential of articaine-loaded poly(epsilon-caprolactone) nanocapules for intraoral topical anesthesia

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniv Mogi das Cruzes UMC-
Autor(es): dc.contributorItapeva Fac Social & Agr Sci FAIT-
Autor(es): dc.contributorUniversidade Estadual de Ponta Grossa (UEPG)-
Autor(es): dc.contributorGuarulhos Univ UNG-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorSao Leopoldo Mandic Res Inst-
Autor(es): dc.creatorSilva, Camila Batista da-
Autor(es): dc.creatorVolpato, Maria Cristina-
Autor(es): dc.creatorMuniz, Bruno Vilela-
Autor(es): dc.creatorSantos, Cleiton Pita dos-
Autor(es): dc.creatorSerpe, Luciano-
Autor(es): dc.creatorNunes Ferreira, Luiz Eduardo-
Autor(es): dc.creatorSilva de Melo, Nathalie Ferreira [UNESP]-
Autor(es): dc.creatorFraceto, Leonardo Fernandes [UNESP]-
Autor(es): dc.creatorGroppo, Francisco Carlos-
Autor(es): dc.creatorFranz-Montan, Michelle-
Data de aceite: dc.date.accessioned2022-02-22T00:58:21Z-
Data de disponibilização: dc.date.available2022-02-22T00:58:21Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-02-10-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0246760-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210041-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210041-
Descrição: dc.descriptionTo determine whether the permeation capacity and analgesic efficacy of articaine (ATC) could be increased and cytotoxicity decreased by encapsulation in poly(e-caprolactone) nanocapsules (ATC(nano)), aiming at local or topical anesthesia in dentistry. Cellular viability was evaluated (using the MTT test and fluorescence microscopy) after 1 h and 24 h exposure of HaCaT cells to ATC, ATC(nano), ATC with epinephrine (ATC(epi)), and ATC in nanocapsules with epinephrine (ATC(nanoepi)). The profiles of permeation of 2% ATC and 2% ATC(nano) across swine esophageal epithelium were determined using Franz-type vertical diffusion cells. Analgesic efficacy was evaluated with a von Frey anesthesiometer in a postoperative pain model in rats, comparing the 2% ATC, 2% ATC(nano), 2% ATC(epi), and 2% ATC(nanoepi) formulations to 4% ATC(epi) (a commercially available formulation). We show that use of the nanocapsules decreased the toxicity of articaine (P<0.0001) and increased its flux (P = 0.0007). The 2% ATC(epi) and 4% ATC(epi) formulations provided higher analgesia success and duration (P<0.05), compared to 2% ATC, 2% ATC(nano), and 2% ATC(nanoepi). Articaine-loaded poly(e-caprolactone) nanocapsules constitute a promising formulation for intraoral topical anesthesia (prior to local anesthetic injection), although it is not effective when injected in inflamed tissues for pain control, such as irreversible pulpitis.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniv Estadual Campinas, UNICAMP, Piracicaba Dent Sch, Dept Biosci, Piracicaba, SP, Brazil-
Descrição: dc.descriptionUniv Mogi das Cruzes UMC, Hlth Sci, Mogi Das Cruzes, SP, Brazil-
Descrição: dc.descriptionItapeva Fac Social & Agr Sci FAIT, Itapeva, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Ponta Grossa, Dept Dent, Ponta Grossa, Parana, Brazil-
Descrição: dc.descriptionGuarulhos Univ UNG, Lab Inflammat & Immunol, Guarulhos, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Environm Engn, Sorocaba, SP, Brazil-
Descrição: dc.descriptionSao Leopoldo Mandic Res Inst, Dept Immunol & Mol Biol, Campinas, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Environm Engn, Sorocaba, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2012/06974-4-
Descrição: dc.descriptionFAPESP: 2012/07310-2-
Descrição: dc.descriptionFAPESP: 2012/02539-1-
Formato: dc.format16-
Idioma: dc.languageen-
Publicador: dc.publisherPublic Library Science-
Relação: dc.relationPlos One-
???dc.source???: dc.sourceWeb of Science-
Título: dc.titlePromising potential of articaine-loaded poly(epsilon-caprolactone) nanocapules for intraoral topical anesthesia-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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