Single-Nucleotide Polymorphism Variations Associated With Specific Genes Putatively Identified Enhanced Genetic Predisposition for 305-Day Milk Yield in the Girolando Crossbreed

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Autor(es): dc.contributorPontificia Univ Catolica Goias-
Autor(es): dc.contributorUniv Estadual Goias-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorCruz, Alex Silva da-
Autor(es): dc.creatorSilva, Danilo Conrado-
Autor(es): dc.creatorMinasi, Lysa Bernardes-
Autor(es): dc.creatorFarias Teixeira, Larissa Kamidia de-
Autor(es): dc.creatorRodrigues, Flavia Melo-
Autor(es): dc.creatorSilva, Claudio Carlos da-
Autor(es): dc.creatorCarmo, Adriana Santana do-
Autor(es): dc.creatorGualberto Barbosa da Silva, Marcos Vinicius-
Autor(es): dc.creatorUtsunomiya, Yuri Tani [UNESP]-
Autor(es): dc.creatorGarcia, Jose Fernando [UNESP]-
Autor(es): dc.creatorCruz, Aparecido Divino da-
Data de aceite: dc.date.accessioned2022-02-22T00:58:18Z-
Data de disponibilização: dc.date.available2022-02-22T00:58:18Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fgene.2020.573344-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/210024-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/210024-
Descrição: dc.descriptionMilk production phenotypes are the main focus of genetic selection in dairy herds, and although there are many genes identified as related to the biology of these traits in pure breeds, little is known about crossbreed animals. This study aimed to identify potential genes associated with the 305-day milk yield in 337 crossbreed Gir x Holstein (Girolando) animals. Milk production records were genotyped for 45,613 single-nucleotide polymorphisms (SNPs). This dataset was used for a genome-wide association study (GWAS) using the 305-day milk yield adjusted for the fixed effects of herd and year and linear and quadratic effects of age at calving (in days) and calving factor averaged per animal. Genes within the significant SNPs were retrieved from the Bos taurus ARS-UCD1.2 assembly (bosTau9) for gene ontology analysis. In summary, the GWAS identified 52 SNPs associated [p <= 10(-4), false discovery rate (FDR) = 8.77%] with milk production, including NUB1 and SLC24A2, which were previously described as related to milk production traits in cattle. The results suggest that SNPs associated mainly with NUB1 and SLC24A2 could be useful to understand milk production in Girolando and used as predictive markers for selecting genetic predisposition for milk yield in Girolando.-
Descrição: dc.descriptionGoias Research Foundation (FAPEG)-
Descrição: dc.descriptionPontifical Catholic University of Goias within its activities of promotion and dissemination scientific research-
Descrição: dc.descriptionPontificia Univ Catolica Goias, Escola Cienclas Agr & Biol, Nucleo Pesquisas Replicon, Genet, Goiania, Go, Brazil-
Descrição: dc.descriptionUniv Estadual Goias, Inst Acad Ciencias Agr & Sustentabilidade, Curso Grad Med Vet, Sao Luis De Montes Beios, Brazil-
Descrição: dc.descriptionUniv Fed Goias, Dept Zootecnia, Escola Vet & Zootecnia, Goiania, Go, Brazil-
Descrição: dc.descriptionEmpresa Brazileira Pesquisa Agr, Ctr Nacl Pesquisa Gado Leite, Juiz De Fora, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista Julio de Mesquite Filho, Fac Med Vet, Dept Apoio Prod & Saude Anim, Aracatuba, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista Julio de Mesquite Filho, Fac Med Vet, Dept Apoio Prod & Saude Anim, Aracatuba, Brazil-
Formato: dc.format7-
Idioma: dc.languageen-
Publicador: dc.publisherFrontiers Media Sa-
Relação: dc.relationFrontiers In Genetics-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectSNP-
Palavras-chave: dc.subjectdairy cattle-
Palavras-chave: dc.subjectindicine-
Palavras-chave: dc.subjectGWAS-
Palavras-chave: dc.subjectselection-
Título: dc.titleSingle-Nucleotide Polymorphism Variations Associated With Specific Genes Putatively Identified Enhanced Genetic Predisposition for 305-Day Milk Yield in the Girolando Crossbreed-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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