An exploratory study of associations with spontaneous preterm birth in primigravid pregnant women with a normal cervical length

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorFed Univ Jundiai-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniv Idaho-
Autor(es): dc.contributorUniv Fed Ceara-
Autor(es): dc.contributorWeill Cornell Med-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorSarmento, Stephanno G. P.-
Autor(es): dc.creatorMoron, Antonio F.-
Autor(es): dc.creatorForney, Larry J.-
Autor(es): dc.creatorHatanaka, Alan R.-
Autor(es): dc.creatorCarvalho, Francisco H. C.-
Autor(es): dc.creatorFranca, Marcelo S.-
Autor(es): dc.creatorK. Hamamoto, Tatiana-
Autor(es): dc.creatorMattar, Rosiane-
Autor(es): dc.creatorLinhares, Iara M.-
Autor(es): dc.creatorMinis, Evelyn-
Autor(es): dc.creatorSanudo, Adriana-
Autor(es): dc.creatorSabino, Ester-
Autor(es): dc.creatorRudge, Marilza V. C. [UNESP]-
Autor(es): dc.creatorWitkin, Steven S.-
Data de aceite: dc.date.accessioned2022-02-22T00:58:12Z-
Data de disponibilização: dc.date.available2022-02-22T00:58:12Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-26-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/14767058.2021.1879786-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209990-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209990-
Descrição: dc.descriptionBackground: Predictors of spontaneous preterm birth in primigravid women remain undetermined. Aim: We evaluated whether biomarkers in vaginal secretions and/or differences in the dominant bacterium in the vaginal microbiome predicted the risk for spontaneous preterm birth in primigravid women with a cervical length >25mm. Study design: In a prospective study, 146 second trimester pregnant women with their first conception and a cervix >25mm were enrolled. The vaginal microbiome composition was characterized by analysis of 16S ribosomal RNA gene sequences. The concentrations of d- and l-lactic acid, matrix metalloproteinase (MMP) 2, 8 and 9 and tissue inhibitor of metalloproteinase (TIMP) 1 and 2 in vaginal secretions were measured by ELISA. Cervical length was determined by vaginal ultrasonography. Pregnancy outcome data were subsequently collected. There was a spontaneous preterm birth (SPTB) in 13 women (8.9%) while in an additional 8 women (5.5%) preterm delivery was medically indicated. Lactobacillus iners was the dominant vaginal bacterium in 61.5% of women with a SPTB but only in 31.2% of those who delivered at term (p = .0354). The vaginal concentration of TIMP-1 (p = .0419) and L-lactic acid (p = .0495) was higher in women with a SPTB as compared to those who delivered at term. Lactobacillus iners dominance was associated with elevated levels of TIMP-1 (p = .0434) and TIMP-2 (p = .0161) and lower levels of D-lactic acid (p < .0001) compared to when L. crispatus was dominant. Conclusion: In this exploratory study of primigravid women, elevations in vaginal TIMP-1 and L- lactic acid and L. iners dominance in the vaginal microbiome are associated with an increased occurrence of SPTB.-
Descrição: dc.descriptionBill and Melinda Gates Foundation-
Descrição: dc.descriptionBrazilian Ministry of Health (DECIT)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionNIH COBRE grant-
Descrição: dc.descriptionFed Univ Jundiai, Dept Obstet & Gynecol, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Fed Sao Paulo, Dept Obstet, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Inst Trop Med, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Idaho, Dept Biol Sci, Moscow, ID 83843 USA-
Descrição: dc.descriptionUniv Idaho, Inst Bioinformat & Evolutionary Studies, Moscow, ID 83843 USA-
Descrição: dc.descriptionUniv Fed Ceara, Dept Obstet & Gynecol, Fortaleza, Ceara, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Dept Obstet & Gynecol, Sch Med, Sao Paulo, Brazil-
Descrição: dc.descriptionWeill Cornell Med, Dept Obstet & Gynecol, New York, NY USA-
Descrição: dc.descriptionUniv Fed Sao Paulo, Dept Prevent Med, Sao Paulo, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Obstet & Gynecol, Sch Med, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Inst Trop Med, Virol Lab LIM 52, Sao Paulo, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Obstet & Gynecol, Sch Med, Botucatu, SP, Brazil-
Descrição: dc.descriptionCNPq: 401626/2013-0-
Descrição: dc.descriptionNIH COBRE grant: P30GM103324-
Formato: dc.format6-
Idioma: dc.languageen-
Publicador: dc.publisherTaylor & Francis Ltd-
Relação: dc.relationJournal Of Maternal-fetal & Neonatal Medicine-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectLactic acid-
Palavras-chave: dc.subjectLactobacillus iners-
Palavras-chave: dc.subjectspontaneous preterm birth-
Palavras-chave: dc.subjectprimigravid-
Palavras-chave: dc.subjecttissue inhibitor of metalloproteinase-
Título: dc.titleAn exploratory study of associations with spontaneous preterm birth in primigravid pregnant women with a normal cervical length-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.