The relevance of miRNAs as promising biomarkers in lip cancer

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorAC Camargo Canc Ctr-
Autor(es): dc.creatorAssao, Agnes-
Autor(es): dc.creatorDomingues, Maria Aparecida Custodio [UNESP]-
Autor(es): dc.creatorMinicucci, Eliana Maria [UNESP]-
Autor(es): dc.creatorMarchi, Fabio Albuquerque-
Autor(es): dc.creatorCoutinho-Camillo, Claudia Malheiros-
Autor(es): dc.creatorOliveira, Denise Tostes-
Data de aceite: dc.date.accessioned2022-02-22T00:57:57Z-
Data de disponibilização: dc.date.available2022-02-22T00:57:57Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-12-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-020-03773-9-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209903-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209903-
Descrição: dc.descriptionObjectives This study aimed to analyze the expression of miR-181b, miR-21, miR-31, and miR-345 in actinic cheilitis with and without epithelial dysplasia and lower lip squamous cell carcinomas, and to verify if the deregulated expression of these miRNAs would be indicative of malignant transformation. Materials and methods The sample was selected from formalin-fixed paraffin-embedded tissues of 19 actinic cheilitis without epithelial dysplasia, 32 actinic cheilitis with epithelial dysplasia, 42 lower lip squamous cell carcinomas, and 10 nonaltered oral mucosa of the lip. The microRNA (miR, miRNA) expression was quantified by real-time RT-PCR and the expression of the selected miRNAs among the groups of actinic cheilitis and lower lip cancer was compared by chi-square. Results A higher expression of miR-181b, miR-31, and miR-345 was found in actinic cheilitis without epithelial dysplasia in comparison to that in actinic cheilitis with epithelial dysplasia and with lower lip cancer. There were no differences in miR-21 expression between actinic cheilitis and lower lip cancer. Hierarchical clustering analysis showed a tendency for a downregulation of miR-181b, miR-21, miR-31, and miR-345 in most patients with lower lip cancers. Conclusions The upregulation of miR-181b, miR-31, and miR-345 expression in actinic cheilitis without epithelial dysplasia and the decrease in the expression of these miRNAs in actinic cheilitis with epithelial dysplasia and in lower lip cancer are potential biomarkers of malignant progression.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUniv Sao Paulo, Bauru Sch Dent, Area Pathol, Dept Surg Stomatol Pathol & Radiol, Alameda Octavio Pinheiro Brisolla 9-75, BR-17012901 Bauru, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Botucatu Med Sch, Dept Histopathol, Sao Paulo, Brazil-
Descrição: dc.descriptionAC Camargo Canc Ctr, Int Res Ctr, Sao Paulo, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Botucatu Med Sch, Dept Histopathol, Sao Paulo, Brazil-
Descrição: dc.descriptionCNPq: 870891/1999-5-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format8-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectOral cancer-
Palavras-chave: dc.subjectmiR-
Palavras-chave: dc.subjectLip cancer-
Palavras-chave: dc.subjectActinic cheilitis-
Título: dc.titleThe relevance of miRNAs as promising biomarkers in lip cancer-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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