Genotoxic and melanic alterations in Lithobates catesbeianus (anura) tadpoles exposed to fipronil insecticide

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.creatorSantos, Arleto T. [UNESP]-
Autor(es): dc.creatorValverde, Bruno S. L. [UNESP]-
Autor(es): dc.creatorDe Oliveira, Classius [UNESP]-
Autor(es): dc.creatorFranco-Belussi, Lilian-
Data de aceite: dc.date.accessioned2022-02-22T00:57:49Z-
Data de disponibilização: dc.date.available2022-02-22T00:57:49Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-05-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11356-020-11948-w-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209862-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209862-
Descrição: dc.descriptionThe aim of this study was to evaluate the genotoxic and morphological systemic effects of both an acute and a chronic exposure of bullfrog tadpoles to fipronil. Lithobates catesbeianus tadpoles had morphological biomarkers (skin, liver, and blood) analyzed at Gosner stages 36-38, when exposed to four different concentrations of Regent (R) 800 WG (80% fipronil): 0.00 (control), 0.04, 0.08, 0.4 mg/L, and four experimental times: 4, 8, 12, and 16 days. Body darkness responded directly to the treatment and exposure time. There was a treatment-dependent decrease in darkness of heads and tails. In relation to the biometric analysis, fipronil induced a decrease in the individual weight and liver mass at the end of the experiments, whereas the hepatosomatic index did not vary according to the treatment. For the exposed animals and for the control group, the area of hepatic melanin increased as exposure time increased. Fipronil has genotoxic effects on L. catesbeianus tadpoles even after short exposure times (e.g., 4 and 8 days), and the main nuclear abnormality is in the anucleate cells. A relevant correlation was observed between genotoxic biomarkers and cutaneous and internal melanin. The frequency of nuclear abnormalities is inversely correlated both with the hepatic melanin area and with the cutaneous melanin of animals. Fipronil has distinct systemic effects on tadpoles based on its concentration, as well as on its exposure time. Such alterations (pigmentation level and rate of erythrocyte abnormality) result in morphological and physiological effects, which may compromise the behavior and survival of the anurans.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniv Estadual Paulista, Programa Posgrad Biodiversidade, Campus Sao Jose Rio Preto, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Biol, Rua Cristovao Colombo 2265, BR-15054000 Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Fed Mato Grosso do Sul, Lab Patol Expt, Campo Grande, MS, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Programa Posgrad Biodiversidade, Campus Sao Jose Rio Preto, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Biol, Rua Cristovao Colombo 2265, BR-15054000 Sao Paulo, Brazil-
Descrição: dc.descriptionCNPq: 304552/2019-4-
Descrição: dc.descriptionFAPESP: 2018/01078-7-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format20072-20081-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer-
Relação: dc.relationEnvironmental Science And Pollution Research-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectBiomarkers-
Palavras-chave: dc.subjectBody darkness-
Palavras-chave: dc.subjectGenotoxicity-
Palavras-chave: dc.subjectMelanin-
Palavras-chave: dc.subjectMelanomacrophages-
Palavras-chave: dc.subjectNuclear abnormalities-
Título: dc.titleGenotoxic and melanic alterations in Lithobates catesbeianus (anura) tadpoles exposed to fipronil insecticide-
Tipo de arquivo: dc.typelivro digital-
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